Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii
Shu, Penghua1; Wei, Xialan1; Xue, Yongho1; Li, Weijie1; Zhang, Jinwen2; Xiang, Ming1; Zhang, Mengke1; Luo, Zengwei1; Li, Yan3; Yao, Guangmin1; Zhang, Yonghui1
2013-07-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:7页码:1303-1312
摘要Twelve new megastigmane sesquiterpenoids, wilsonols A L (1-12), were isolated from the leaves of Cinnamomum wilsonii, along with seven known analogues (13-19). The structures of compounds 1-12 were established by spectroscopic analyses. The absolute configurations of 1-5 were determined by single-crystal X-ray diffraction analysis with Cu K alpha irradiation, and the absolute configurations of 6-12 were determined by the modified Mosher's method. Compounds 1-9 and 13-19 were evaluated for in vitro cytotmdcity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480, and compared against the Beas-2B immortalized (noncancerous) human bronchial epithelial cell line. Compound 13 exhibited IC50 values ranging from 2.5 to 12 mu M and selectivity indices of >10 against SMMC-7721, A-549, and MCF-7 cell lines. Selected compounds were evaluated for in vitro immunomodulatory activity.
关键词Apollonias-barbujana Subavenium Cassia C-13-norisoprenoids Constituents Glucosides Glycosides
资助信息Scientific Research Foundation for the Returned Oversea Chinese Scholars, State Education Ministry of China [2010-1561]; Program for Youth Chutian Scholar of Hubei Province of China [2011-6]; Program for New Century Excellent Talents in University, State Education Ministry of China [NCET-2008-0224]
收录类别SCI ; IC
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16747
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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Shu, Penghua,Wei, Xialan,Xue, Yongho,et al. Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(7):1303-1312.
APA Shu, Penghua.,Wei, Xialan.,Xue, Yongho.,Li, Weijie.,Zhang, Jinwen.,...&Zhang, Yonghui.(2013).Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii.JOURNAL OF NATURAL PRODUCTS,76(7),1303-1312.
MLA Shu, Penghua,et al."Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii".JOURNAL OF NATURAL PRODUCTS 76.7(2013):1303-1312.
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