| Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii | |
Shu, Penghua1; Wei, Xialan1; Xue, Yongho1; Li, Weijie1; Zhang, Jinwen2; Xiang, Ming1; Zhang, Mengke1; Luo, Zengwei1; Li, Yan3 ; Yao, Guangmin1; Zhang, Yonghui1
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| 通讯作者 | Yao, GM (reprint author), Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China. ; gyap@mail.hust.edu.cn ; zhangyh@mails.tjmu.edu.cn |
| 2013-07-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 76期号:7页码:1303-1312 |
| 摘要 | Twelve new megastigmane sesquiterpenoids, wilsonols A L (1-12), were isolated from the leaves of Cinnamomum wilsonii, along with seven known analogues (13-19). The structures of compounds 1-12 were established by spectroscopic analyses. The absolute configurations of 1-5 were determined by single-crystal X-ray diffraction analysis with Cu K alpha irradiation, and the absolute configurations of 6-12 were determined by the modified Mosher's method. Compounds 1-9 and 13-19 were evaluated for in vitro cytotmdcity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480, and compared against the Beas-2B immortalized (noncancerous) human bronchial epithelial cell line. Compound 13 exhibited IC50 values ranging from 2.5 to 12 mu M and selectivity indices of >10 against SMMC-7721, A-549, and MCF-7 cell lines. Selected compounds were evaluated for in vitro immunomodulatory activity. |
| 关键词 | Apollonias-barbujana Subavenium Cassia C-13-norisoprenoids Constituents Glucosides Glycosides |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000322562900012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16747 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shu, Penghua,Wei, Xialan,Xue, Yongho,et al. Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(7):1303-1312. |
| APA | Shu, Penghua.,Wei, Xialan.,Xue, Yongho.,Li, Weijie.,Zhang, Jinwen.,...&Zhang, Yonghui.(2013).Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii.JOURNAL OF NATURAL PRODUCTS,76(7),1303-1312. |
| MLA | Shu, Penghua,et al."Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii".JOURNAL OF NATURAL PRODUCTS 76.7(2013):1303-1312. |
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