| Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production | |
Xu, Junju1,2; Su, Jia1; Li, Yan1 ; Tan, Ninghua1
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| 通讯作者 | Xu, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; nhtan@mail.kib.ac.cn |
| 2013-07-01 | |
| 发表期刊 | CHEMISTRY OF NATURAL COMPOUNDS
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| ISSN | 0009-3130 |
| 卷号 | 49期号:3页码:457-461 |
| 摘要 | Phytochemical investigation of the fruits of Alpinia oxyphylla led to the isolation of 12 eremophilane sesquiterpenes, including a novel noreremophilane sesquiterpene, (4R*,5R*)-7-acetyl-4,5-dimethyl-4,5,8,9-tetrahydronaphthalen-2(3H)-one (oxyphyllanone A, 1), along with eleven known compounds (2-12). Among them, compounds 2-6, 9, and 11 were isolated from this genus for the first time. Their structures were determined on the basis of spectroscopic analysis, including 2D NMR spectroscopic techniques. The tested compounds 2-12 showed different inhibitory activity against NO production in interferon-gamma- and lipopolysaccharide-induced RAW264.7 macrophage cells, and compound 11 was the most active one with IC50 value of 4.61 mu g/mL. |
| 关键词 | Zingiberaceae Alpinia Oxyphylla Eremophilane Sesquiterpene Oxyphyllanone a Inhibition Of No Production |
| 学科领域 | Chemistry, Medicinal ; Chemistry, Organic |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000322679200014 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16743 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Junju,Su, Jia,Li, Yan,et al. Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production[J]. CHEMISTRY OF NATURAL COMPOUNDS,2013,49(3):457-461. |
| APA | Xu, Junju,Su, Jia,Li, Yan,&Tan, Ninghua.(2013).Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production.CHEMISTRY OF NATURAL COMPOUNDS,49(3),457-461. |
| MLA | Xu, Junju,et al."Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production".CHEMISTRY OF NATURAL COMPOUNDS 49.3(2013):457-461. |
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