Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production
Xu, Junju1,2; Su, Jia1; Li, Yan1; Tan, Ninghua1
2013-07-01
发表期刊CHEMISTRY OF NATURAL COMPOUNDS
ISSN0009-3130
卷号49期号:3页码:457-461
摘要Phytochemical investigation of the fruits of Alpinia oxyphylla led to the isolation of 12 eremophilane sesquiterpenes, including a novel noreremophilane sesquiterpene, (4R*,5R*)-7-acetyl-4,5-dimethyl-4,5,8,9-tetrahydronaphthalen-2(3H)-one (oxyphyllanone A, 1), along with eleven known compounds (2-12). Among them, compounds 2-6, 9, and 11 were isolated from this genus for the first time. Their structures were determined on the basis of spectroscopic analysis, including 2D NMR spectroscopic techniques. The tested compounds 2-12 showed different inhibitory activity against NO production in interferon-gamma- and lipopolysaccharide-induced RAW264.7 macrophage cells, and compound 11 was the most active one with IC50 value of 4.61 mu g/mL.
关键词Zingiberaceae Alpinia Oxyphylla Eremophilane Sesquiterpene Oxyphyllanone a Inhibition Of No Production
资助信息National Natural Science Foundation of China [U1032602, 31000159, 91013002, 30725048]; National New Drug Innovation Major Project of China [2011ZX09307-002-002]; National Basic Research Program of China [2009CB522300]
收录类别SCI ; IC
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16743
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China
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Xu, Junju,Su, Jia,Li, Yan,et al. Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production[J]. CHEMISTRY OF NATURAL COMPOUNDS,2013,49(3):457-461.
APA Xu, Junju,Su, Jia,Li, Yan,&Tan, Ninghua.(2013).Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production.CHEMISTRY OF NATURAL COMPOUNDS,49(3),457-461.
MLA Xu, Junju,et al."Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production".CHEMISTRY OF NATURAL COMPOUNDS 49.3(2013):457-461.
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