Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity
Chen, Wen1; Yang, Li-Juan2,3; Li, Yan4; Wang, Xue-Quan1; Wang, Shao-Jie2,3; Wan, Wei-Chao1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
Corresponding AuthorYang, XD (reprint author), Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China. ; xdyang@ynu.edu.cn
2013-08-01
Source PublicationLETTERS IN DRUG DESIGN & DISCOVERY
ISSN1570-1808
Volume10Issue:7Pages:561-571
AbstractA series of novel hybrid compounds between tricyclic indeno[5,6-b] furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl group were vital for modulating cytotoxic activity. In particular, hybrid compound 26 was found to be the most potent compound against 5 strains human tumor cell lines and more active than cisplatin (DDP), while compound 18 was more selective towards breast carcinoma (MCF-7) and colon carcinoma (SW480) with IC50 value 3.4-fold and 4.3-fold more sensitive to DDP.
KeywordHybrid Compound Imidazole Synthesis Indeno[5 Cytotoxic Activity 6-b]Furan Structure-activity Relationships
Subject AreaChemistry, Medicinal
Indexed BySCI
Language英语
WOS IDWOS:000320915500002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16729
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resource, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
2.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China
3.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Chen, Wen,Yang, Li-Juan,Li, Yan,et al. Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2013,10(7):561-571.
APA Chen, Wen.,Yang, Li-Juan.,Li, Yan.,Wang, Xue-Quan.,Wang, Shao-Jie.,...&Yang, Xiao-Dong.(2013).Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity.LETTERS IN DRUG DESIGN & DISCOVERY,10(7),561-571.
MLA Chen, Wen,et al."Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity".LETTERS IN DRUG DESIGN & DISCOVERY 10.7(2013):561-571.
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