| Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity | |
Chen, Wen1; Yang, Li-Juan2,3; Li, Yan4 ; Wang, Xue-Quan1; Wang, Shao-Jie2,3; Wan, Wei-Chao1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
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| 通讯作者 | Yang, XD (reprint author), Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China. ; xdyang@ynu.edu.cn |
| 2013-08-01 | |
| 发表期刊 | LETTERS IN DRUG DESIGN & DISCOVERY
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| ISSN | 1570-1808 |
| 卷号 | 10期号:7页码:561-571 |
| 摘要 | A series of novel hybrid compounds between tricyclic indeno[5,6-b] furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl group were vital for modulating cytotoxic activity. In particular, hybrid compound 26 was found to be the most potent compound against 5 strains human tumor cell lines and more active than cisplatin (DDP), while compound 18 was more selective towards breast carcinoma (MCF-7) and colon carcinoma (SW480) with IC50 value 3.4-fold and 4.3-fold more sensitive to DDP. |
| 关键词 | Hybrid Compound Imidazole Synthesis Indeno[5 Cytotoxic Activity 6-b]Furan Structure-activity Relationships |
| 学科领域 | Chemistry, Medicinal |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000320915500002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16729 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resource, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China 2.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China 3.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Wen,Yang, Li-Juan,Li, Yan,et al. Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2013,10(7):561-571. |
| APA | Chen, Wen.,Yang, Li-Juan.,Li, Yan.,Wang, Xue-Quan.,Wang, Shao-Jie.,...&Yang, Xiao-Dong.(2013).Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity.LETTERS IN DRUG DESIGN & DISCOVERY,10(7),561-571. |
| MLA | Chen, Wen,et al."Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity".LETTERS IN DRUG DESIGN & DISCOVERY 10.7(2013):561-571. |
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