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题名: Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity
作者: Chen, Wen1; Yang, Li-Juan2, 3; null(李艳)4; Wang, Xue-Quan1; Wang, Shao-Jie2, 3; Wan, Wei-Chao1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
刊名: LETTERS IN DRUG DESIGN & DISCOVERY
关键词: Hybrid compound ; Imidazole ; Indeno[5,6-b]furan ; Synthesis ; Cytotoxic activity ; Structure-activity relationships
英文摘要: A series of novel hybrid compounds between tricyclic indeno[5,6-b] furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl group were vital for modulating cytotoxic activity. In particular, hybrid compound 26 was found to be the most potent compound against 5 strains human tumor cell lines and more active than cisplatin (DDP), while compound 18 was more selective towards breast carcinoma (MCF-7) and colon carcinoma (SW480) with IC50 value 3.4-fold and 4.3-fold more sensitive to DDP.
出版日期: 2013-08-01
卷号: 10, 期号:7, 页码:561-571
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal
ISSN号: 1570-1808
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16729
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resource, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
2.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China
3.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

Recommended Citation:
Chen, Wen; Yang, Li-Juan; Li, Yan; Wang, Xue-Quan; Wang, Shao-Jie; Wan, Wei-Chao; Zhang, Hong-Bin; Yang, Xiao-Dong.Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity,LETTERS IN DRUG DESIGN & DISCOVERY,2013,10(7):561-571
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