Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds
Chen, Wen1; Deng, Xiao-Yan1; Li, Yan2; Yang, Li-Juan3,4; Wan, Wei-Chao1; Wang, Xue-Quan1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
2013-08-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号23期号:15页码:4297-4302
摘要A series of novel hybrid compounds of 2-phenyl-3-alkylbenzofuran and imidazole or triazole were prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the 2-ethyl-imidazole ring, and substitution of the imidazolyl-3-position with a 2-bromobenzyl or naphthylacyl group, were vital for modulating inhibitory activity. In particular, hybrid compound 31 was found to be the most potent derivative with IC50 values of 0.08-0.55 mu M against five strains human tumor cell lines and was found to be more selective against breast carcinoma (MCF-7) and colon carcinoma (SW480) (IC50 values 40.8-fold and 40.1-fold lower than cisplatin (DDP)). (C) 2013 Elsevier Ltd. All rights reserved.
关键词Hybrid Compound Benzofuran Imidazole Triazole Structure-activity Relationships
资助信息NSFC [30960460, 20925205, 21062026]; NSFYN [2010GA014, 2012FB113]; PRTTSTYN [2009C1120]; NBRPC (973 Program) [2009CB522300]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16727
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China
4.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
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Chen, Wen,Deng, Xiao-Yan,Li, Yan,et al. Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(15):4297-4302.
APA Chen, Wen.,Deng, Xiao-Yan.,Li, Yan.,Yang, Li-Juan.,Wan, Wei-Chao.,...&Yang, Xiao-Dong.(2013).Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(15),4297-4302.
MLA Chen, Wen,et al."Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.15(2013):4297-4302.
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