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题名: Two new flavonols, including one flavan dimer, from the roots of Indigofera stachyodes
作者: Qiu, Lu1, 2; Liang, Yan1; Tang, Gui-Hua2; Yuan, Chun-Mao2; Zhang, Yu2; Hao, Xiao-Yan1; null(郝小江)2; He, Hong-Ping2
刊名: PHYTOCHEMISTRY LETTERS
关键词: Indigofera stachyodes ; Flavonol ; Flavan dimer ; Hepatoprotective effect
英文摘要: A new flavan dimer, 2 alpha,3 alpha-epoxyflavan-5,7,3',4'-tetraol-(4 beta -> 8)-flavan-5 '',7 '',4'''-triol (1), and a new flavonol, 3-O-(3-nitropropanoyl)-2,3-cis-5,7,3',4'-tetrahydroxyflavan (2), together with a known compound, 2 alpha,3 alpha-epoxy-5,7,3',4'-tetrahydroxyflavan-(4 beta -> 8)-epicatechin (3), were isolated from the roots of Indigofera stachyodes. Their structures were elucidated by spectroscopic techniques including MS, 1D NMR, and 2D NMR. Compounds 2 and 3 were evaluated to determine their protective effects against carbon tetrachloride (CCl4)-induced hepatotoxicity in the human liver cell line HL-7702. The results showed that 2 and 3 could protect HL-7702 cells from injury induced by CCl4, with cell survival rates of 122.0% and 72.5%, respectively. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
出版日期: 2013-08-01
卷号: 6, 期号:3, 页码:368-371
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Plant Sciences
ISSN号: 1874-3900
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16725
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Guiyang Med Coll, Sch Pharm, Guiyang 550004, Guizhou, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resource West Chi, Kunming 650201, Yunnan, Peoples R China

Recommended Citation:
Qiu, Lu; Liang, Yan; Tang, Gui-Hua; Yuan, Chun-Mao; Zhang, Yu; Hao, Xiao-Yan; Hao, Xiao-Jiang; He, Hong-Ping.Two new flavonols, including one flavan dimer, from the roots of Indigofera stachyodes,PHYTOCHEMISTRY LETTERS,2013,6(3):368-371
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