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题名: A prenylated xanthone and antiproliferative compounds from leaves of Pentadesma butyracea
作者: Tala, Michel Feussi1, 2; Wabo, Hippolyte Kamdem2; Zeng, Guang-Zhi1; Ji, Chang-Jiu1; Tane, Pierre2; Tan, Ning-Hua1
刊名: PHYTOCHEMISTRY LETTERS
关键词: Pentadesma butyracea ; Guttiferae ; Butyraxanthone F ; Xanthones ; Antiproliferative activity
英文摘要: A new prenylated xanthone, butyraxanthone F (1) together with 20 known compounds were isolated from the leaves of Pentadesma butyracea. Their identification was achieved by spectroscopic means and comparison of the data with literature or by direct comparison on TLC with authentic samples. To the best of our knowledge, this is the first report of 2-hydroxy-2,3-dihydrosqualene (17) from a natural source. Compounds 2-6 and 11-16 were found for the first time in this genus. The antiproliferative activity of the crude extract, fractions and some isolated compounds was evaluated against three human cancer cell lines, BGC-823, Hela and A549. The crude extract, fractions B and C showed weak activities. Globuxanthone (2) and 30-epi-cambogin (7) were found to be the most active compounds on the three cancer cells. The effect of 2 on Hela cells and that of 7 on BGC-823 cells were noteworthy. The antiproliferative potential of allanxanthone A (3), ergosta-4,6,8(14),22-tetraen-3-one (14) and 2-hydroxy-2,3-dihydrosqualene (17) against BGC-823 and Hela cells could be classified as moderate-to-weak. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
出版日期: 2013-08-01
卷号: 6, 期号:3, 页码:326-330
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Plant Sciences
ISSN号: 1874-3900
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16721
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Dschang, Dept Chem, Dschang, Cameroon

Recommended Citation:
Tala, Michel Feussi; Wabo, Hippolyte Kamdem; Zeng, Guang-Zhi; Ji, Chang-Jiu; Tane, Pierre; Tan, Ning-Hua.A prenylated xanthone and antiproliferative compounds from leaves of Pentadesma butyracea,PHYTOCHEMISTRY LETTERS,2013,6(3):326-330
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文件名: Tala-2013-A prenylated xanthon.pdf
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