| A prenylated xanthone and antiproliferative compounds from leaves of Pentadesma butyracea | |
| Tala, Michel Feussi1,2; Wabo, Hippolyte Kamdem2; Zeng, Guang-Zhi1; Ji, Chang-Jiu1; Tane, Pierre2; Tan, Ning-Hua1 | |
| 通讯作者 | Wabo, HK (reprint author), Univ Dschang, Dept Chem, POB 67, Dschang, Cameroon. ; hkamdemw@yahoo.ca ; nhtan@mail.kib.ac.cn |
| 2013-08-01 | |
| 发表期刊 | PHYTOCHEMISTRY LETTERS
 |
| ISSN | 1874-3900 |
| 卷号 | 6期号:3页码:326-330 |
| 摘要 | A new prenylated xanthone, butyraxanthone F (1) together with 20 known compounds were isolated from the leaves of Pentadesma butyracea. Their identification was achieved by spectroscopic means and comparison of the data with literature or by direct comparison on TLC with authentic samples. To the best of our knowledge, this is the first report of 2-hydroxy-2,3-dihydrosqualene (17) from a natural source. Compounds 2-6 and 11-16 were found for the first time in this genus. The antiproliferative activity of the crude extract, fractions and some isolated compounds was evaluated against three human cancer cell lines, BGC-823, Hela and A549. The crude extract, fractions B and C showed weak activities. Globuxanthone (2) and 30-epi-cambogin (7) were found to be the most active compounds on the three cancer cells. The effect of 2 on Hela cells and that of 7 on BGC-823 cells were noteworthy. The antiproliferative potential of allanxanthone A (3), ergosta-4,6,8(14),22-tetraen-3-one (14) and 2-hydroxy-2,3-dihydrosqualene (17) against BGC-823 and Hela cells could be classified as moderate-to-weak. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
| 关键词 | Pentadesma Butyracea Guttiferae Butyraxanthone f Xanthones Antiproliferative Activity |
| 学科领域 | Biochemistry & Molecular Biology ; Plant Sciences |
| DOI | 10.1016/j.phytol.2013.03.016 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322312900004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16721 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Dschang, Dept Chem, Dschang, Cameroon |
| 推荐引用方式 GB/T 7714 | Tala, Michel Feussi,Wabo, Hippolyte Kamdem,Zeng, Guang-Zhi,et al. A prenylated xanthone and antiproliferative compounds from leaves of Pentadesma butyracea[J]. PHYTOCHEMISTRY LETTERS,2013,6(3):326-330. |
| APA | Tala, Michel Feussi,Wabo, Hippolyte Kamdem,Zeng, Guang-Zhi,Ji, Chang-Jiu,Tane, Pierre,&Tan, Ning-Hua.(2013).A prenylated xanthone and antiproliferative compounds from leaves of Pentadesma butyracea.PHYTOCHEMISTRY LETTERS,6(3),326-330. |
| MLA | Tala, Michel Feussi,et al."A prenylated xanthone and antiproliferative compounds from leaves of Pentadesma butyracea".PHYTOCHEMISTRY LETTERS 6.3(2013):326-330. |
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