Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds
Liu, Lan-Xiang1; Wang, Xue-Quan1; Yan, Ju-Ming2; Li, Yan2; Sun, Cheng-Jun1; Chen, Wen1; Zhou, Bei1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
2013-08-01
发表期刊EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN0223-5234
卷号66页码:423-437
摘要A series of novel hybrid compounds between dibenzo[b,d]furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring, and the substitution of the imidazolyl-3-position with a naphthylacyl or 4-methoxyphenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 60 was found to be the most potent derivatives against all of human tumor cell lines investigated, while compound 49 was found to be more selective against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721). Compound 60 can induce the G1 phase cell cycle arrest and apoptosis in SMMC-7721 cells. (C) 2013 Elsevier Masson SAS. All rights reserved.
关键词Hybrid Compound Imidazole Dibenzo[b Antitumor Activities d]Furan Structure-activity Relationships
资助信息Natural Science Foundation of China [30960460, 20925205, 21062026]; Natural Science Foundation of Yunnan Province [2012FB113, 2010GA014]; National Basic Research Program of China (973 Program) [2009CB522300]; Project of Recruited Top Talent of Sciences and Technology of Yunnan Province [2009C1120]; CAS; Natural Science Foundation of China(30960460; Natural Science Foundation of Yunnan Province(2012FB113; National Basic Research Program of China (973 Program)(2009CB522300); Project of Recruited Top Talent of Sciences and Technology of Yunnan Province(2009C1120); CAS; 20925205; 2010GA014); 21062026)
学科领域Chemistry, Medicinal
DOI10.1016/j.ejmech.2013.06.011
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000323628500045
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16709
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式
GB/T 7714
Liu, Lan-Xiang,Wang, Xue-Quan,Yan, Ju-Ming,et al. Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,66:423-437.
APA Liu, Lan-Xiang.,Wang, Xue-Quan.,Yan, Ju-Ming.,Li, Yan.,Sun, Cheng-Jun.,...&Yang, Xiao-Dong.(2013).Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,66,423-437.
MLA Liu, Lan-Xiang,et al."Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 66(2013):423-437.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Liu-2013-Synthesis a(3339KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Lan-Xiang]的文章
[Wang, Xue-Quan]的文章
[Yan, Ju-Ming]的文章
百度学术
百度学术中相似的文章
[Liu, Lan-Xiang]的文章
[Wang, Xue-Quan]的文章
[Yan, Ju-Ming]的文章
必应学术
必应学术中相似的文章
[Liu, Lan-Xiang]的文章
[Wang, Xue-Quan]的文章
[Yan, Ju-Ming]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。