Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds
Liu, Lan-Xiang1; Wang, Xue-Quan1; Yan, Ju-Ming2; Li, Yan2; Sun, Cheng-Jun1; Chen, Wen1; Zhou, Bei1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
Corresponding AuthorLi, Y (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China. ; liyanb@mail.kib.ac.cn ; xdyang@ynu.edu.cn
2013-08-01
Source PublicationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN0223-5234
Volume66Pages:423-437
AbstractA series of novel hybrid compounds between dibenzo[b,d]furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring, and the substitution of the imidazolyl-3-position with a naphthylacyl or 4-methoxyphenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 60 was found to be the most potent derivatives against all of human tumor cell lines investigated, while compound 49 was found to be more selective against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721). Compound 60 can induce the G1 phase cell cycle arrest and apoptosis in SMMC-7721 cells. (C) 2013 Elsevier Masson SAS. All rights reserved.
KeywordHybrid Compound Imidazole Dibenzo[b Antitumor Activities d]Furan Structure-activity Relationships
Subject AreaChemistry, Medicinal
DOI10.1016/j.ejmech.2013.06.011
Indexed BySCI ; IC
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000323628500045
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16709
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Liu, Lan-Xiang,Wang, Xue-Quan,Yan, Ju-Ming,et al. Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,66:423-437.
APA Liu, Lan-Xiang.,Wang, Xue-Quan.,Yan, Ju-Ming.,Li, Yan.,Sun, Cheng-Jun.,...&Yang, Xiao-Dong.(2013).Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,66,423-437.
MLA Liu, Lan-Xiang,et al."Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 66(2013):423-437.
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