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题名: Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds
作者: Liu, Lan-Xiang1; Wang, Xue-Quan1; Yan, Ju-Ming2; null(李艳)2; Sun, Cheng-Jun1; Chen, Wen1; Zhou, Bei1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
刊名: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
关键词: Hybrid compound ; Dibenzo[b,d]furan ; Imidazole ; Antitumor activities ; Structure-activity relationships
英文摘要: A series of novel hybrid compounds between dibenzo[b,d]furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring, and the substitution of the imidazolyl-3-position with a naphthylacyl or 4-methoxyphenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 60 was found to be the most potent derivatives against all of human tumor cell lines investigated, while compound 49 was found to be more selective against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721). Compound 60 can induce the G1 phase cell cycle arrest and apoptosis in SMMC-7721 cells. (C) 2013 Elsevier Masson SAS. All rights reserved.
出版日期: 2013-08-01
卷号: 66, 页码:423-437
DOI标识: 10.1016/j.ejmech.2013.06.011
语种: 英语
ISSN号: 0223-5234
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16709
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

Recommended Citation:
Liu, Lan-Xiang; Wang, Xue-Quan; Yan, Ju-Ming; Li, Yan; Sun, Cheng-Jun; Chen, Wen; Zhou, Bei; Zhang, Hong-Bin; Yang, Xiao-Dong.Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds,EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,66():423-437
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文件名: Liu-2013-Synthesis and antitu.pdf
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