| Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds | |
Liu, Lan-Xiang1; Wang, Xue-Quan1; Yan, Ju-Ming2; Li, Yan2 ; Sun, Cheng-Jun1; Chen, Wen1; Zhou, Bei1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
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| 通讯作者 | Li, Y (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China. ; liyanb@mail.kib.ac.cn ; xdyang@ynu.edu.cn |
| 2013-08-01 | |
| 发表期刊 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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| ISSN | 0223-5234 |
| 卷号 | 66页码:423-437 |
| 摘要 | A series of novel hybrid compounds between dibenzo[b,d]furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring, and the substitution of the imidazolyl-3-position with a naphthylacyl or 4-methoxyphenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 60 was found to be the most potent derivatives against all of human tumor cell lines investigated, while compound 49 was found to be more selective against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721). Compound 60 can induce the G1 phase cell cycle arrest and apoptosis in SMMC-7721 cells. (C) 2013 Elsevier Masson SAS. All rights reserved. |
| 关键词 | Hybrid Compound Imidazole Dibenzo[b Antitumor Activities d]Furan Structure-activity Relationships |
| 学科领域 | Chemistry, Medicinal |
| DOI | 10.1016/j.ejmech.2013.06.011 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000323628500045 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16709 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Lan-Xiang,Wang, Xue-Quan,Yan, Ju-Ming,et al. Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,66:423-437. |
| APA | Liu, Lan-Xiang.,Wang, Xue-Quan.,Yan, Ju-Ming.,Li, Yan.,Sun, Cheng-Jun.,...&Yang, Xiao-Dong.(2013).Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,66,423-437. |
| MLA | Liu, Lan-Xiang,et al."Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 66(2013):423-437. |
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