| Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma | |
Wang, Hong-Ling1,2; Geng, Chang-An1 ; Ma, Yun-Bao1; Zhang, Xue-Mei1; Chen, Ji-Jun1
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| Corresponding Author | Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; chenjj@mail.kib.ac.cn |
| 2013-09-01 | |
| Source Publication | FITOTERAPIA
 |
| ISSN | 0367-326X |
| Volume | 89Pages:183-187 |
| Abstract | Three new secoiridoids, swermacrolactones A-C (1-3), together with fourteen known compounds were isolated from Swertia macrosperma. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, MS, 1D and 2D NMR). By anti-HBV assay on the Hep G 2.2.15 cell line in vitro, the most active compound, luteolin (9), inhibited the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 0.02 and 0.02 mM, respectively. (c) 2013 Elsevier B.V. All rights reserved. |
| Keyword | Secoiridoids Swermacrolactones A-c Anti-hbv Activity Swertia Macrosperma Gentianaceae |
| Subject Area | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS ID | WOS:000323856500020 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/16677 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Hong-Ling,Geng, Chang-An,Ma, Yun-Bao,et al. Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma[J]. FITOTERAPIA,2013,89:183-187. |
| APA | Wang, Hong-Ling,Geng, Chang-An,Ma, Yun-Bao,Zhang, Xue-Mei,&Chen, Ji-Jun.(2013).Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma.FITOTERAPIA,89,183-187. |
| MLA | Wang, Hong-Ling,et al."Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma".FITOTERAPIA 89(2013):183-187. |
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