Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma
Wang, Hong-Ling1,2; Geng, Chang-An1; Ma, Yun-Bao1; Zhang, Xue-Mei1; Chen, Ji-Jun1
Corresponding AuthorChen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; chenjj@mail.kib.ac.cn
2013-09-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume89Pages:183-187
AbstractThree new secoiridoids, swermacrolactones A-C (1-3), together with fourteen known compounds were isolated from Swertia macrosperma. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, MS, 1D and 2D NMR). By anti-HBV assay on the Hep G 2.2.15 cell line in vitro, the most active compound, luteolin (9), inhibited the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 0.02 and 0.02 mM, respectively. (c) 2013 Elsevier B.V. All rights reserved.
KeywordSecoiridoids Swermacrolactones A-c Anti-hbv Activity Swertia Macrosperma Gentianaceae
Subject AreaChemistry, Medicinal ; Pharmacology & Pharmacy
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000323856500020
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16677
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Wang, Hong-Ling,Geng, Chang-An,Ma, Yun-Bao,et al. Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma[J]. FITOTERAPIA,2013,89:183-187.
APA Wang, Hong-Ling,Geng, Chang-An,Ma, Yun-Bao,Zhang, Xue-Mei,&Chen, Ji-Jun.(2013).Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma.FITOTERAPIA,89,183-187.
MLA Wang, Hong-Ling,et al."Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma".FITOTERAPIA 89(2013):183-187.
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