Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity
Cao, Tuan-Wu1,2; Geng, Chang-An1; Jiang, Fu-Qiang1; Ma, Yun-Bao1; He, Kang1; Zhou, Ning-Jia1,2; Zhang, Xue-Mei1; Zhou, Jun1; Chen, Ji-Jun1
2013-09-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号89页码:175-182
摘要Four new triterpenoids, sweriyunnangenin A (1), sweriyunnanosides A (2), B (3) and C (4), along with nineteen known compounds (5-23) were isolated from Swertia yunnanensis. Based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [alpha](D)), the structures of sweriyunnangenin A (1), sweriyunnanosides A (2), B (3) and C (4) were elucidated as taraxer-14-ene-3 alpha,6 beta-diol, oleanolic acid 28-O-beta-D-glucopyranosyl-(1 -> 2)-O-beta-D-glucopyranoside, 2 alpha,3 beta-di-hydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranosyl(1 -> 6)-beta-D-glucopyranosyl (1 -> 6)-beta-D-glucopyranosyl(1 -> 2)-beta-D-glucopyranoside and hederagenin 28-O-beta-D-glucopyranosyl (1 -> 6)-beta-D-glucopyranosyl(1 -> 6)-beta-D-glucopyranosyl(1 -> 2)-beta-D-glucopyranoside, respectively. Twenty-two compounds were evaluated for their anti-HBV activities on the HepG 2.2.15 cell line in vitro, of which nine compounds showed potent anti-HBV activities. Compounds 1, 5-6, 14-16 and 19 showed activities against the secretion of HBsAg (IC50 values from 0.10 to 1.76 mM) and HBeAg (IC50 values from 0.04 to 1.41 mM), and compounds 11 and 13-16 exhibited significant inhibition on HBV DNA replication (IC50 values from 0.01 to 0.09 mM). (c) 2013 Elsevier B.V. All rights reserved.
关键词Swertia Yunnanensis Gentianaceae Triterpenoids Sweriyunnanosides A-c Anti-hbv Activity
资助信息National Science Foundation of China for Distinguished Young Scholars [81025023]; National Natural Science Foundation of China and Yunnan Province [U0832603]; West Light Foundation of the Chinese Academy of Sciences; International Foundation for Science [F/5202-1]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000323856500019
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16675
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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Cao, Tuan-Wu,Geng, Chang-An,Jiang, Fu-Qiang,et al. Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity[J]. FITOTERAPIA,2013,89:175-182.
APA Cao, Tuan-Wu.,Geng, Chang-An.,Jiang, Fu-Qiang.,Ma, Yun-Bao.,He, Kang.,...&Chen, Ji-Jun.(2013).Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity.FITOTERAPIA,89,175-182.
MLA Cao, Tuan-Wu,et al."Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity".FITOTERAPIA 89(2013):175-182.
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