| Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity | |
Cao, Tuan-Wu1,2; Geng, Chang-An1 ; Jiang, Fu-Qiang1; Ma, Yun-Bao1; He, Kang1; Zhou, Ning-Jia1,2; Zhang, Xue-Mei1; Zhou, Jun1; Chen, Ji-Jun1
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| 通讯作者 | Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China. ; chenjj@mail.kib.ac.cn |
| 2013-09-01 | |
| 发表期刊 | FITOTERAPIA
 |
| ISSN | 0367-326X |
| 卷号 | 89页码:175-182 |
| 摘要 | Four new triterpenoids, sweriyunnangenin A (1), sweriyunnanosides A (2), B (3) and C (4), along with nineteen known compounds (5-23) were isolated from Swertia yunnanensis. Based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [alpha](D)), the structures of sweriyunnangenin A (1), sweriyunnanosides A (2), B (3) and C (4) were elucidated as taraxer-14-ene-3 alpha,6 beta-diol, oleanolic acid 28-O-beta-D-glucopyranosyl-(1 -> 2)-O-beta-D-glucopyranoside, 2 alpha,3 beta-di-hydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranosyl(1 -> 6)-beta-D-glucopyranosyl (1 -> 6)-beta-D-glucopyranosyl(1 -> 2)-beta-D-glucopyranoside and hederagenin 28-O-beta-D-glucopyranosyl (1 -> 6)-beta-D-glucopyranosyl(1 -> 6)-beta-D-glucopyranosyl(1 -> 2)-beta-D-glucopyranoside, respectively. Twenty-two compounds were evaluated for their anti-HBV activities on the HepG 2.2.15 cell line in vitro, of which nine compounds showed potent anti-HBV activities. Compounds 1, 5-6, 14-16 and 19 showed activities against the secretion of HBsAg (IC50 values from 0.10 to 1.76 mM) and HBeAg (IC50 values from 0.04 to 1.41 mM), and compounds 11 and 13-16 exhibited significant inhibition on HBV DNA replication (IC50 values from 0.01 to 0.09 mM). (c) 2013 Elsevier B.V. All rights reserved. |
| 关键词 | Swertia Yunnanensis Gentianaceae Triterpenoids Sweriyunnanosides A-c Anti-hbv Activity |
| 学科领域 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323856500019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16675 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Tuan-Wu,Geng, Chang-An,Jiang, Fu-Qiang,et al. Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity[J]. FITOTERAPIA,2013,89:175-182. |
| APA | Cao, Tuan-Wu.,Geng, Chang-An.,Jiang, Fu-Qiang.,Ma, Yun-Bao.,He, Kang.,...&Chen, Ji-Jun.(2013).Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity.FITOTERAPIA,89,175-182. |
| MLA | Cao, Tuan-Wu,et al."Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity".FITOTERAPIA 89(2013):175-182. |
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