Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus

doi:10.1016/j.tet.2013.07.006

	Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus
	Xu, Hui-Min 1,2; Zeng, Guang-Zhi 1; Zhou, Wen-Bing 1,2; He, Wen-Jun 1; Tan, Ning-Hua 1
通讯作者	Tan, NH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; nhtan@mail.kib.ac.cn
	2013-09-16
发表期刊	TETRAHEDRON
ISSN	0040-4020
卷号	69 期号:37 页码:7964-7969
摘要	During further investigation on the methanol extract of roots and rhizomes of Aster tataricus, six new chlorinated cyclopentapeptides, designated as astins K-P (9-14), together with eight known derivatives, astins A-H (1-8), were isolated. Structures of the new cyclopeptides were established using extensive spectroscopic methods, and the absolute configurations were determined by the advanced Marfey's method. Astin P (14) represents a unique cyclopentapeptide linking as cyclo-(L-Pro (Cl-2)(1)-L-allo-Thr(2)-L-Ser(3)-L-beta-Phe(4)-L-Ava(5)). Astin B(2) showed cytotoxicity against BGC-823 cell with IC50 value of 19.2 mu g/ml. Astin C (3) exhibited cytotoxicity on HCT-116 and BGC-823 cells with IC50 values of 13.4 and 3.3 mu g/ml, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
关键词	Aster Tataricus Cyclopentapeptides Compositae Astins K-p Cytotoxicity
学科领域	Chemistry, Organic
DOI	10.1016/j.tet.2013.07.006
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000323140100010
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16659
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xu, Hui-Min,Zeng, Guang-Zhi,Zhou, Wen-Bing,et al. Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus[J]. TETRAHEDRON,2013,69(37):7964-7969.
APA	Xu, Hui-Min,Zeng, Guang-Zhi,Zhou, Wen-Bing,He, Wen-Jun,&Tan, Ning-Hua.(2013).Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus.TETRAHEDRON,69(37),7964-7969.
MLA	Xu, Hui-Min,et al."Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus".TETRAHEDRON 69.37(2013):7964-7969.

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