Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus
Xu, Hui-Min1,2; Zeng, Guang-Zhi1; Zhou, Wen-Bing1,2; He, Wen-Jun1; Tan, Ning-Hua1
2013-09-16
发表期刊TETRAHEDRON
ISSN0040-4020
卷号69期号:37页码:7964-7969
摘要During further investigation on the methanol extract of roots and rhizomes of Aster tataricus, six new chlorinated cyclopentapeptides, designated as astins K-P (9-14), together with eight known derivatives, astins A-H (1-8), were isolated. Structures of the new cyclopeptides were established using extensive spectroscopic methods, and the absolute configurations were determined by the advanced Marfey's method. Astin P (14) represents a unique cyclopentapeptide linking as cyclo-(L-Pro (Cl-2)(1)-L-allo-Thr(2)-L-Ser(3)-L-beta-Phe(4)-L-Ava(5)). Astin B(2) showed cytotoxicity against BGC-823 cell with IC50 value of 19.2 mu g/ml. Astin C (3) exhibited cytotoxicity on HCT-116 and BGC-823 cells with IC50 values of 13.4 and 3.3 mu g/ml, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Aster Tataricus Cyclopentapeptides Compositae Astins K-p Cytotoxicity
资助信息National Basic Research Program of China [2013CB127505, 2009CB522300]; National Natural Science Foundation of China [U1032602, 91013002, 21102152, 30725048]; National New Drug Innovation Major Project of China [2011ZX09307-002-02]; Foundation of Chinese Academy of Sciences (Hundred Talents Program); Natural Science Foundation of Yunnan Province [2012GA003, 2011FZ206]
收录类别SCI ; IC
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16659
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Xu, Hui-Min,Zeng, Guang-Zhi,Zhou, Wen-Bing,et al. Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus[J]. TETRAHEDRON,2013,69(37):7964-7969.
APA Xu, Hui-Min,Zeng, Guang-Zhi,Zhou, Wen-Bing,He, Wen-Jun,&Tan, Ning-Hua.(2013).Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus.TETRAHEDRON,69(37),7964-7969.
MLA Xu, Hui-Min,et al."Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus".TETRAHEDRON 69.37(2013):7964-7969.
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