| Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells | |
Peng, Xing-Rong1,2; Liu, Jie-Qing1; Han, Zhong-Hui1,3; Yuan, Xiao-Xi1,2; Luo, Huai-Rong1,2 ; Qiu, Ming-Hua1,2
| |
| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China. ; mhchiu@mail.kib.ac.cn |
| 2013-11-15 | |
| 发表期刊 | FOOD CHEMISTRY
 |
| ISSN | 0308-8146 |
| 卷号 | 141期号:2页码:920-926 |
| 摘要 | Ganoderma resinaceum Boud. (Polyporeseae) has long been used for antioxidant, immunoregulation and liver protection. From the fruiting bodies of G. resinaceum, eight new lanostanoids, lucidones D-G (1-4), 7-oxo-ganoderic acid Z(2) (5), 7-oxo-ganoderic acid Z(3) (6), ganoderesin A (7), and ganoderesin B (8), together with six known lanostanoids (9-14) were isolated. The structures of new compounds were elucidated through extensive spectroscopic analysis. In an in vitro model, ganoderesin B (8), ganoderol B (10) and lucidone A (11) showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC). However, compounds 8, 10 and 11 displayed no anti-oxidant activities by DPPH assay. Mean-while, activation for PXR (Pregnane X Receptor) of ganoderesin B (8), ganoderol B (10) and lucidone A (11) was evaluated; ganoderol (10) exhibited a vital activation for PXR-induced CYP3A4 expression. These results suggested that GTs (Ganoderma triterpenoids) exhibited hepatoprotective activities by lowering ALT and AST levels. (C) 2013 Elsevier Ltd. All rights reserved. |
| 关键词 | Ganoderma Resinaceum Ganoderma Triterpenoids Hepatoprotective Activities Cyp3a4 Hepg2 Cells |
| 学科领域 | Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000321803500038 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16651 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Xing-Rong,Liu, Jie-Qing,Han, Zhong-Hui,et al. Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells[J]. FOOD CHEMISTRY,2013,141(2):920-926. |
| APA | Peng, Xing-Rong,Liu, Jie-Qing,Han, Zhong-Hui,Yuan, Xiao-Xi,Luo, Huai-Rong,&Qiu, Ming-Hua.(2013).Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells.FOOD CHEMISTRY,141(2),920-926. |
| MLA | Peng, Xing-Rong,et al."Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells".FOOD CHEMISTRY 141.2(2013):920-926. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Peng-2013-Protective（375KB） | 开放获取 | -- | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论