Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells
Peng, Xing-Rong1,2; Liu, Jie-Qing1; Han, Zhong-Hui1,3; Yuan, Xiao-Xi1,2; Luo, Huai-Rong1,2; Qiu, Ming-Hua1,2
Corresponding AuthorQiu, MH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China. ; mhchiu@mail.kib.ac.cn
2013-11-15
Source PublicationFOOD CHEMISTRY
ISSN0308-8146
Volume141Issue:2Pages:920-926
AbstractGanoderma resinaceum Boud. (Polyporeseae) has long been used for antioxidant, immunoregulation and liver protection. From the fruiting bodies of G. resinaceum, eight new lanostanoids, lucidones D-G (1-4), 7-oxo-ganoderic acid Z(2) (5), 7-oxo-ganoderic acid Z(3) (6), ganoderesin A (7), and ganoderesin B (8), together with six known lanostanoids (9-14) were isolated. The structures of new compounds were elucidated through extensive spectroscopic analysis. In an in vitro model, ganoderesin B (8), ganoderol B (10) and lucidone A (11) showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC). However, compounds 8, 10 and 11 displayed no anti-oxidant activities by DPPH assay. Mean-while, activation for PXR (Pregnane X Receptor) of ganoderesin B (8), ganoderol B (10) and lucidone A (11) was evaluated; ganoderol (10) exhibited a vital activation for PXR-induced CYP3A4 expression. These results suggested that GTs (Ganoderma triterpenoids) exhibited hepatoprotective activities by lowering ALT and AST levels. (C) 2013 Elsevier Ltd. All rights reserved.
KeywordGanoderma Resinaceum Ganoderma Triterpenoids Hepatoprotective Activities Cyp3a4 Hepg2 Cells
Subject AreaChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000321803500038
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16651
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Peng, Xing-Rong,Liu, Jie-Qing,Han, Zhong-Hui,et al. Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells[J]. FOOD CHEMISTRY,2013,141(2):920-926.
APA Peng, Xing-Rong,Liu, Jie-Qing,Han, Zhong-Hui,Yuan, Xiao-Xi,Luo, Huai-Rong,&Qiu, Ming-Hua.(2013).Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells.FOOD CHEMISTRY,141(2),920-926.
MLA Peng, Xing-Rong,et al."Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells".FOOD CHEMISTRY 141.2(2013):920-926.
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