Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells
Peng, Xing-Rong1,2; Liu, Jie-Qing1; Han, Zhong-Hui1,3; Yuan, Xiao-Xi1,2; Luo, Huai-Rong1,2; Qiu, Ming-Hua1,2
2013-11-15
发表期刊FOOD CHEMISTRY
ISSN0308-8146
卷号141期号:2页码:920-926
摘要Ganoderma resinaceum Boud. (Polyporeseae) has long been used for antioxidant, immunoregulation and liver protection. From the fruiting bodies of G. resinaceum, eight new lanostanoids, lucidones D-G (1-4), 7-oxo-ganoderic acid Z(2) (5), 7-oxo-ganoderic acid Z(3) (6), ganoderesin A (7), and ganoderesin B (8), together with six known lanostanoids (9-14) were isolated. The structures of new compounds were elucidated through extensive spectroscopic analysis. In an in vitro model, ganoderesin B (8), ganoderol B (10) and lucidone A (11) showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC). However, compounds 8, 10 and 11 displayed no anti-oxidant activities by DPPH assay. Mean-while, activation for PXR (Pregnane X Receptor) of ganoderesin B (8), ganoderol B (10) and lucidone A (11) was evaluated; ganoderol (10) exhibited a vital activation for PXR-induced CYP3A4 expression. These results suggested that GTs (Ganoderma triterpenoids) exhibited hepatoprotective activities by lowering ALT and AST levels. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Ganoderma Resinaceum Ganoderma Triterpenoids Hepatoprotective Activities Cyp3a4 Hepg2 Cells
资助信息NSFC [81172940]; CAS [KSCX2-YW-G-038, KSCX2-YW-R-194]; Department of Science and Technology in Yunnan Province [20080A007]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ14]
学科领域Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
收录类别SCI
语种英语
WOS研究方向Chemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS类目Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS记录号WOS:000321803500038
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16651
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China
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Peng, Xing-Rong,Liu, Jie-Qing,Han, Zhong-Hui,et al. Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells[J]. FOOD CHEMISTRY,2013,141(2):920-926.
APA Peng, Xing-Rong,Liu, Jie-Qing,Han, Zhong-Hui,Yuan, Xiao-Xi,Luo, Huai-Rong,&Qiu, Ming-Hua.(2013).Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells.FOOD CHEMISTRY,141(2),920-926.
MLA Peng, Xing-Rong,et al."Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells".FOOD CHEMISTRY 141.2(2013):920-926.
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