Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells

	Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells
	Peng, Xing-Rong 1,2; Liu, Jie-Qing 1; Han, Zhong-Hui 1,3; Yuan, Xiao-Xi 1,2; Luo, Huai-Rong1,2 ; Qiu, Ming-Hua1,2
通讯作者	Qiu, MH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China. ; mhchiu@mail.kib.ac.cn
	2013-11-15
发表期刊	FOOD CHEMISTRY
ISSN	0308-8146
卷号	141 期号:2 页码:920-926
摘要	Ganoderma resinaceum Boud. (Polyporeseae) has long been used for antioxidant, immunoregulation and liver protection. From the fruiting bodies of G. resinaceum, eight new lanostanoids, lucidones D-G (1-4), 7-oxo-ganoderic acid Z(2) (5), 7-oxo-ganoderic acid Z(3) (6), ganoderesin A (7), and ganoderesin B (8), together with six known lanostanoids (9-14) were isolated. The structures of new compounds were elucidated through extensive spectroscopic analysis. In an in vitro model, ganoderesin B (8), ganoderol B (10) and lucidone A (11) showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC). However, compounds 8, 10 and 11 displayed no anti-oxidant activities by DPPH assay. Mean-while, activation for PXR (Pregnane X Receptor) of ganoderesin B (8), ganoderol B (10) and lucidone A (11) was evaluated; ganoderol (10) exhibited a vital activation for PXR-induced CYP3A4 expression. These results suggested that GTs (Ganoderma triterpenoids) exhibited hepatoprotective activities by lowering ALT and AST levels. (C) 2013 Elsevier Ltd. All rights reserved.
关键词	Ganoderma Resinaceum Ganoderma Triterpenoids Hepatoprotective Activities Cyp3a4 Hepg2 Cells
学科领域	Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
收录类别	SCI
语种	英语
WOS记录号	WOS:000321803500038
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16651
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Peng, Xing-Rong,Liu, Jie-Qing,Han, Zhong-Hui,et al. Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells[J]. FOOD CHEMISTRY,2013,141(2):920-926.
APA	Peng, Xing-Rong,Liu, Jie-Qing,Han, Zhong-Hui,Yuan, Xiao-Xi,Luo, Huai-Rong,&Qiu, Ming-Hua.(2013).Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells.FOOD CHEMISTRY,141(2),920-926.
MLA	Peng, Xing-Rong,et al."Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells".FOOD CHEMISTRY 141.2(2013):920-926.

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