Acetylcholineestarase-Inhibiting Alkaloids from Lycoris radiata Delay Paralysis of Amyloid Beta-Expressing Transgenic C. elegans CL4176
Xin, Lijuan1,4; Yamujala, Ritupriya2; Wang, Yuehu3; Wang, Huan3; Wu, Wen-Hsuan2; Lawton, Michael A.4; Long, Chunlin1,3; Di, Rong4
2013-05-13
发表期刊PLOS ONE
ISSN1932-6203
卷号8期号:5页码:e63874
摘要The limited symptom relief and side effects of current Alzheimer's disease (AD) medications warrant urgent discovery and study of new anti-AD agents. The "cholinergic hypothesis'' of AD prompts us to search for plant-derived acetylcholineesterase (AChE) inhibitors such as galanthamine that has been licensed in Europe for AD treatment. We used the unique amyloid beta-expressing transgenic C. elegans CL4176, which exhibits paralysis when human A(beta 1-42) is induced, to study two natural benzylphenethylamine alkaloids isolated from Lycoris radiata (L' Her.) Herb, galanthamine and haemanthidine, and their synthetic derivatives 1,2-Di-O-acetyllycorine and 1-O-acetyllycorine for their anti-paralysis effects. Our data indicate that these Lycoris compounds effectively delay the paralysis of CL4176 worms upon temperature up-shift, and prolong the lives of these transgenic worms. Lycoris compounds were shown to significantly inhibit the gene expression of ace-1 and ace-2. Additionally, the Lycoris compounds may modulate inflammatory and stress-related gene expressions to combat the A beta-toxicity in C. elegans.
关键词Alzheimers-disease Caenorhabditis-elegans Acetylcholinesterase Inhibitors Amaryllidaceae Alkaloids Oxidative Stress Pc12 Cells Peptide Genes Peroxide Hypothesis
资助信息National Natural Science Foundation of China [31161140345, 31070288, 20972166]; Ministry of Education of China [B08044, MUC985-9, MUC98506-01000101]
学科领域Multidisciplinary Sciences
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000319036100053
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16595
专题资源植物与生物技术所级重点实验室
作者单位1.Minzu Univ China, Coll Life & Environm Sci, Beijing, Peoples R China
2.Rutgers State Univ, New Brunswick Grad Sch, New Brunswick, NJ 08903 USA
3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Beijing 100864, Peoples R China
4.Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol & Pathol, New Brunswick, NJ 08903 USA
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Xin, Lijuan,Yamujala, Ritupriya,Wang, Yuehu,et al. Acetylcholineestarase-Inhibiting Alkaloids from Lycoris radiata Delay Paralysis of Amyloid Beta-Expressing Transgenic C. elegans CL4176[J]. PLOS ONE,2013,8(5):e63874.
APA Xin, Lijuan.,Yamujala, Ritupriya.,Wang, Yuehu.,Wang, Huan.,Wu, Wen-Hsuan.,...&Di, Rong.(2013).Acetylcholineestarase-Inhibiting Alkaloids from Lycoris radiata Delay Paralysis of Amyloid Beta-Expressing Transgenic C. elegans CL4176.PLOS ONE,8(5),e63874.
MLA Xin, Lijuan,et al."Acetylcholineestarase-Inhibiting Alkaloids from Lycoris radiata Delay Paralysis of Amyloid Beta-Expressing Transgenic C. elegans CL4176".PLOS ONE 8.5(2013):e63874.
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