| Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides |
| Han Wen-Xia; Zhu Hua-Jie
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| 通讯作者 | Zhu, HJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Reasources West C, Kunming 650204, Peoples R China.
; zhuhuajie@hotmail.com
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| 2013-02-10
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| 发表期刊 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
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| ISSN | 0251-0790
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| 卷号 | 34期号:2页码:346-353 |
| 摘要 | Phenolic beta-D-glucopyranosides exist widely in nature and exhibit many important physiological activities. For example, gastrodia isolated from Pholidota chinensis Lind1. has such a sketch and play an important bioactivity on nerve system. Recently, we found another phenolic beta-D-glucopyranoside from the Pulicaria insignis which had definite anti-HCV activity. Based on the results achieved in our research group, we tried to design and synthesize series of phenolic beta-D-glucopyranosides to wish to find new and better bioactive compounds used in anti-HCV study. Fifteen novel natural analogues of phenolic beta-D-glucopyranosides were synthesized from phenolic aglycones and acetobromo-alpha-D-glucose or beta-D-glucose pentaacetate. Their structures were characterized by MS, H-1 NMR and C-13 NMR. Preliminary anti-HCV activity tests showed that compounds 8a and 10a exhibited definite anti-viral activity, their EC50 are 21 and 9.4 mu mol/L, and the CC50 of them are 150.4 and 145.9 mu mol/L, respectively. |
| 关键词 | Beta-d-glucoside
Phenolic Glycoside
Anti-hcv Activity
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| 学科领域 | Chemistry, Multidisciplinary
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| DOI | 10.7503/cjcu20120972
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| 收录类别 | SCI
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| 语种 | 英语
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| WOS记录号 | WOS:000317085400015
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16583
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| 专题 | 植物化学与西部植物资源持续利用国家重点实验室
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| 作者单位 | Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Reasources West C, Kunming 650204, Peoples R China
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推荐引用方式
GB/T 7714 |
Han Wen-Xia,Zhu Hua-Jie. Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2013,34(2):346-353.
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| APA |
Han Wen-Xia,&Zhu Hua-Jie.(2013).Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,34(2),346-353.
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| MLA |
Han Wen-Xia,et al."Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 34.2(2013):346-353.
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