Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides
Han Wen-Xia; Zhu Hua-Jie
Corresponding AuthorZhu, HJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Reasources West C, Kunming 650204, Peoples R China. ; zhuhuajie@hotmail.com
2013-02-10
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
Volume34Issue:2Pages:346-353
AbstractPhenolic beta-D-glucopyranosides exist widely in nature and exhibit many important physiological activities. For example, gastrodia isolated from Pholidota chinensis Lind1. has such a sketch and play an important bioactivity on nerve system. Recently, we found another phenolic beta-D-glucopyranoside from the Pulicaria insignis which had definite anti-HCV activity. Based on the results achieved in our research group, we tried to design and synthesize series of phenolic beta-D-glucopyranosides to wish to find new and better bioactive compounds used in anti-HCV study. Fifteen novel natural analogues of phenolic beta-D-glucopyranosides were synthesized from phenolic aglycones and acetobromo-alpha-D-glucose or beta-D-glucose pentaacetate. Their structures were characterized by MS, H-1 NMR and C-13 NMR. Preliminary anti-HCV activity tests showed that compounds 8a and 10a exhibited definite anti-viral activity, their EC50 are 21 and 9.4 mu mol/L, and the CC50 of them are 150.4 and 145.9 mu mol/L, respectively.
KeywordBeta-d-glucoside Phenolic Glycoside Anti-hcv Activity
Subject AreaChemistry, Multidisciplinary
DOI10.7503/cjcu20120972
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000317085400015
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16583
Collection植物化学与西部植物资源持续利用国家重点实验室
AffiliationChinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Reasources West C, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Han Wen-Xia,Zhu Hua-Jie. Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2013,34(2):346-353.
APA Han Wen-Xia,&Zhu Hua-Jie.(2013).Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,34(2),346-353.
MLA Han Wen-Xia,et al."Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 34.2(2013):346-353.
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