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题名: Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides
作者: Han Wen-Xia1; Zhu Hua-Jie1
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
关键词: beta-D-Glucoside ; Phenolic glycoside ; Anti-HCV activity
英文摘要: Phenolic beta-D-glucopyranosides exist widely in nature and exhibit many important physiological activities. For example, gastrodia isolated from Pholidota chinensis Lind1. has such a sketch and play an important bioactivity on nerve system. Recently, we found another phenolic beta-D-glucopyranoside from the Pulicaria insignis which had definite anti-HCV activity. Based on the results achieved in our research group, we tried to design and synthesize series of phenolic beta-D-glucopyranosides to wish to find new and better bioactive compounds used in anti-HCV study. Fifteen novel natural analogues of phenolic beta-D-glucopyranosides were synthesized from phenolic aglycones and acetobromo-alpha-D-glucose or beta-D-glucose pentaacetate. Their structures were characterized by MS, H-1 NMR and C-13 NMR. Preliminary anti-HCV activity tests showed that compounds 8a and 10a exhibited definite anti-viral activity, their EC50 are 21 and 9.4 mu mol/L, and the CC50 of them are 150.4 and 145.9 mu mol/L, respectively.
出版日期: 2013-02-10
卷号: 34, 期号:2, 页码:346-353
DOI标识: 10.7503/cjcu20120972
语种: 英语
ISSN号: 0251-0790
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16583
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Reasources West C, Kunming 650204, Peoples R China

Recommended Citation:
Han Wen-Xia; Zhu Hua-Jie.Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides,CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2013,34(2):346-353
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