Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents
Wang, Xue-Quan1; Liu, Lan-Xiang1; Li, Yan2; Sun, Cheng-Jun1; Chen, Wen1; Li, Liang1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
2013-04-01
发表期刊EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN0223-5234
卷号62页码:111-121
摘要A series of novel hybrid compounds between 2-benzylbenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-positionwith a naphthylacyl or 4-methoxyphenacyl group were vital for modulating cytotoxic activity In particular, hybrid compounds 46 and 47 were found to be the most potent derivatives against 5 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activities selectively against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721), respectively. (C) 2013 Elsevier Masson SAS. All rights reserved.
关键词Hybrid Compound 2-benzylbenzofuran Imidazole Cytotoxic Activities Structure-activity Relationships
资助信息National Natural Science Foundation of China [30960460, 20925205, 21062026]; Natural Science Foundation of Yunnan Province [2010GA014, 2012FB113]; National Basic Research Program of China (973 Program) [2009CB522300]
学科领域Chemistry, Medicinal
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000318577500012
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被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16577
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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Wang, Xue-Quan,Liu, Lan-Xiang,Li, Yan,et al. Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,62:111-121.
APA Wang, Xue-Quan.,Liu, Lan-Xiang.,Li, Yan.,Sun, Cheng-Jun.,Chen, Wen.,...&Yang, Xiao-Dong.(2013).Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,62,111-121.
MLA Wang, Xue-Quan,et al."Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 62(2013):111-121.
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