Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents

	Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents
	Wang, Xue-Quan 1; Liu, Lan-Xiang 1; Li, Yan2 ; Sun, Cheng-Jun 1; Chen, Wen 1; Li, Liang 1; Zhang, Hong-Bin 1; Yang, Xiao-Dong 1
通讯作者	Yang, XD (reprint author), Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China. ; xdyang@ynu.edu.cn
	2013-04-01
发表期刊	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN	0223-5234
卷号	62 页码:111-121
摘要	A series of novel hybrid compounds between 2-benzylbenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-positionwith a naphthylacyl or 4-methoxyphenacyl group were vital for modulating cytotoxic activity In particular, hybrid compounds 46 and 47 were found to be the most potent derivatives against 5 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activities selectively against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721), respectively. (C) 2013 Elsevier Masson SAS. All rights reserved.
关键词	Hybrid Compound 2-benzylbenzofuran Imidazole Cytotoxic Activities Structure-activity Relationships
学科领域	Chemistry, Medicinal
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000318577500012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16577
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xue-Quan,Liu, Lan-Xiang,Li, Yan,et al. Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,62:111-121.
APA	Wang, Xue-Quan.,Liu, Lan-Xiang.,Li, Yan.,Sun, Cheng-Jun.,Chen, Wen.,...&Yang, Xiao-Dong.(2013).Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,62,111-121.
MLA	Wang, Xue-Quan,et al."Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 62(2013):111-121.

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