Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents
Wang, Xue-Quan1; Liu, Lan-Xiang1; Li, Yan2; Sun, Cheng-Jun1; Chen, Wen1; Li, Liang1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
Corresponding AuthorYang, XD (reprint author), Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China. ; xdyang@ynu.edu.cn
2013-04-01
Source PublicationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN0223-5234
Volume62Pages:111-121
AbstractA series of novel hybrid compounds between 2-benzylbenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-positionwith a naphthylacyl or 4-methoxyphenacyl group were vital for modulating cytotoxic activity In particular, hybrid compounds 46 and 47 were found to be the most potent derivatives against 5 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activities selectively against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721), respectively. (C) 2013 Elsevier Masson SAS. All rights reserved.
KeywordHybrid Compound 2-benzylbenzofuran Imidazole Cytotoxic Activities Structure-activity Relationships
Subject AreaChemistry, Medicinal
Indexed BySCI ; IC
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000318577500012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16577
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xue-Quan,Liu, Lan-Xiang,Li, Yan,et al. Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,62:111-121.
APA Wang, Xue-Quan.,Liu, Lan-Xiang.,Li, Yan.,Sun, Cheng-Jun.,Chen, Wen.,...&Yang, Xiao-Dong.(2013).Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,62,111-121.
MLA Wang, Xue-Quan,et al."Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 62(2013):111-121.
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