| Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction | |
Li, Shenghong1 ; Qiu, Shengxiang2; Yao, Ping3; Sun, Handong1; Fong, Harry H. S.4; Zhang, Hongjie5
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| 通讯作者 | Zhang, HJ (reprint author), Hong Kong Baptist Univ, Sch Chinese Med, 7 Baptist Univ Rd, Kowloon Tong, Hong Kong, Peoples R China. ; zhanghj@hkbu.edu.hk |
| 2013 | |
| 发表期刊 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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| ISSN | 1741-427X |
| 页码 | 432829 |
| 摘要 | As part of our continuing efforts in the search for potential biologically active compounds from medicinal plants, we have isolated 18 compounds including two novel nitrogen containing diterpenes from extracts of the fruits of Vitex agnus-castus. These isolates, along with our previously obtained novel compound vitexlactam A (1), were evaluated for potential biological effects, including cancer chemoprevention. Chemically, the nitrogenous isolates were found to be two labdane diterpene alkaloids, each containing an alpha,beta-unsaturated gamma-lactammoiety. Structurally, they were elucidated to be 9 alpha-hydroxy-13(14)-labden-16,15-amide (2) and 6 beta-acetoxy-9 alpha-hydroxy-13(14)-labden-15,16-amide (3), which were named vitexlactams B and C, respectively. The 15 known isolates were identified as vitexilactone (4), rotundifuran (5), 8-epi-manoyl oxide (6), vitetrifolin D (7), spathulenol (8), cis-dihydro-dehydro-diconiferylalcohol-9-O-beta-D-glucoside (9), luteolin-7-O-glucoside (10), 5-hydroxy-3,6,7,4'-tetramethoxyflavone (11), casticin (12), artemetin (13), aucubin (14), agnuside (15), beta-sitosterol (16), p-hydroxybenzoic acid (17), and p-hydroxybenzoic acid glucose ester (18). All compound structures were determined/identified on the basis of 1D and/or 2D NMR and mass spectrometry techniques. Compounds 6, 8, 9, and 18 were reported from a Vitex spieces for the first time. The cancer chemopreventive potentials of these isolates were evaluated for NADP(H): quinone oxidoreductase type 1 (QR1) induction activity. Compound 7 demonstrated promising QR1 induction effect, while the new compound vitexlactam (3) was only slightly active. |
| 关键词 | Constituents Flavonoids |
| 学科领域 | Integrative & Complementary Medicine |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317513200001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16575 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China 3.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China 4.Univ Illinois, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA 5.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shenghong,Qiu, Shengxiang,Yao, Ping,et al. Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013:432829. |
| APA | Li, Shenghong,Qiu, Shengxiang,Yao, Ping,Sun, Handong,Fong, Harry H. S.,&Zhang, Hongjie.(2013).Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,432829. |
| MLA | Li, Shenghong,et al."Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013):432829. |
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