Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts

	Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts
	Nian, Yin1 ; Zhu, Hui 2; Tang, Wen-Ru 2; Luo, Yin 2; Du, Jiang 3; Qiu, Ming-Hua1
通讯作者	Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem Plant Resources West Chin, Kunming 650201, Peoples R China. ; mhchiu@mail.kib.ac.cn
	2013-05-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	76 期号:5 页码:896-902
摘要	Nine new triterpene derivatives, yunnanterpenes A-F (1-6), 15,16-seco-cimiterpenes A and B (7, 8), and cimilactone C (9), and 15 known analogues (10-24) were isolated from the aerial parts of Cimicifuga yunnanensis. The new structures were established using a combination of MS, NMR, and single-crystal X-ray diffraction techniques. WT MEFs (wildtype mouse embryonic fibroblasts) and tumorigenic cell lines p53(-/-)+H-RasV12 and ps3(-/-)+p53(N236S)+H-RasV12 were used for evaluating active structures, targeting p53(N236S) (corresponding to p53(N239S) in humans) mutation. Compound 5 showed nonselective activities against these cell lines, with IC50 values of 5.8, 8.6, and 6.0 mu M, respectively. Compound 4 exhibited greater selectivity against the p53(-/-)+p53(N236S)+H-RasV12 cells (IC50 5.5 mu M) than against the WT MEFs cells (IC50 14.3 mu M).
关键词	Simplex Wormsk 9 19-cyclolanostane Derivatives Cycloartane Triterpenoids Constituents Glycosides Racemosa Dahurica Roots
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000319650600012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16547
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem Plant Resources West Chin, Kunming 650201, Peoples R China 2.Kunming Univ Sci & Technol, Fac Med, Lab Mol Genet Aging & Tumor, Kunming 650500, Peoples R China 3.Dengzhanhua Pharmaceut Co Ltd, Res Inst Yunnan Biovalley, Kunming 650224, Peoples R China
推荐引用方式 GB/T 7714	Nian, Yin,Zhu, Hui,Tang, Wen-Ru,et al. Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(5):896-902.
APA	Nian, Yin,Zhu, Hui,Tang, Wen-Ru,Luo, Yin,Du, Jiang,&Qiu, Ming-Hua.(2013).Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts.JOURNAL OF NATURAL PRODUCTS,76(5),896-902.
MLA	Nian, Yin,et al."Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts".JOURNAL OF NATURAL PRODUCTS 76.5(2013):896-902.

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