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题名: Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts
作者: Nian, Yin1; Zhu, Hui2; Tang, Wen-Ru2; Luo, Yin2; Du, Jiang3; null(邱明华)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: SIMPLEX WORMSK ; 9 ; 19-CYCLOLANOSTANE DERIVATIVES ; CYCLOARTANE TRITERPENOIDS ; CONSTITUENTS ; GLYCOSIDES ; RACEMOSA ; DAHURICA ; ROOTS
英文摘要: Nine new triterpene derivatives, yunnanterpenes A-F (1-6), 15,16-seco-cimiterpenes A and B (7, 8), and cimilactone C (9), and 15 known analogues (10-24) were isolated from the aerial parts of Cimicifuga yunnanensis. The new structures were established using a combination of MS, NMR, and single-crystal X-ray diffraction techniques. WT MEFs (wildtype mouse embryonic fibroblasts) and tumorigenic cell lines p53(-/-)+H-RasV12 and ps3(-/-)+p53(N236S)+H-RasV12 were used for evaluating active structures, targeting p53(N236S) (corresponding to p53(N239S) in humans) mutation. Compound 5 showed nonselective activities against these cell lines, with IC50 values of 5.8, 8.6, and 6.0 mu M, respectively. Compound 4 exhibited greater selectivity against the p53(-/-)+p53(N236S)+H-RasV12 cells (IC50 5.5 mu M) than against the WT MEFs cells (IC50 14.3 mu M).
出版日期: 2013-05-01
卷号: 76, 期号:5, 页码:896-902
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16547
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem Plant Resources West Chin, Kunming 650201, Peoples R China
2.Kunming Univ Sci & Technol, Fac Med, Lab Mol Genet Aging & Tumor, Kunming 650500, Peoples R China
3.Dengzhanhua Pharmaceut Co Ltd, Res Inst Yunnan Biovalley, Kunming 650224, Peoples R China

Recommended Citation:
Nian, Yin; Zhu, Hui; Tang, Wen-Ru; Luo, Yin; Du, Jiang; Qiu, Ming-Hua.Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts,JOURNAL OF NATURAL PRODUCTS,2013,76(5):896-902
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