Comparison of Physicochemical Characteristics and Anticoagulant Activities of Polysaccharides from Three Sea Cucumbers
Luo, Lan1,2; Wu, Mingyi1; Xu, Li1; Lian, Wu1; Xiang, Jingying1; Lu, Feng1; Gao, Na1; Xiao, Chuang1; Wang, Shengmin2; Zhao, Jinhua1
2013-02-01
发表期刊MARINE DRUGS
ISSN1660-3397
卷号11期号:2页码:399-417
摘要In order to search for sulfated polysaccharides in different invertebrate connective tissues and to examine their biological activities, we have isolated three types of polysaccharides from the body wall of the three sea cucumbers Holothuria edulis, Apostichopus japonicas and Holothuria nobilis. The physicochemical properties and anticoagulant activities of these polysaccharides were examined and compared. The chemical composition analysis and nuclear magnetic resonance (NMR) analysis indicate that two types of polysaccharides, sulfated fucan and fucosylated chondroitin sulfate (FuCS), were found in all of the three species and in addition a neutral glycan was observed in H. edulis. The neutral alpha-glucan was firstly obtained from sea cucumber. The same type of polysaccharides from different species of sea cucumbers have similar physicochemical properties and anticoagulant activities, but those of different types of glycans are significantly different, possibly due to their different monosaccharide compositions, electric charges and average molecular weights. The FuCSs have stronger anticoagulant activities than the sulfated fucans, although the molecular sizes of the FuCSs are lower than those the sulfated fucans, whereas the neutral glucan has no activity, as expected from the absence of sulfate. Thus, anticoagulant activities of the different type of polysaccharides are likely to relate to monosaccharide composition and sulfate content. Preliminary analysis suggests that the sulfation patterns of the FuCSs may result in the difference in anticoagulant activities. Our data could help elucidate the structure-activity relationship of the sea cucumber polysaccharides.
关键词Sea Cucumber Polysaccharide Fucosylated Chondroitin Sulfate Sulfated Fucan Glucan Anticoagulant Activity
资助信息Yunnan Provincial Science and Technology Department in China [2010CI116, 2012BC011, 2012FB177]; National Natural Science Foundation of China [81102372]; West Light Foundation of the Chinese Academy of Sciences; Yunnan Provincial Science and Technology Department in China(2010CI116; National Natural Science Foundation of China(81102372); West Light Foundation of the Chinese Academy of Sciences; 2012BC011; 2012FB177)
学科领域Chemistry, Medicinal
DOI10.3390/md11020399
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000315396800009
引用统计
被引频次:69[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16541
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 611756, Peoples R China
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Luo, Lan,Wu, Mingyi,Xu, Li,et al. Comparison of Physicochemical Characteristics and Anticoagulant Activities of Polysaccharides from Three Sea Cucumbers[J]. MARINE DRUGS,2013,11(2):399-417.
APA Luo, Lan.,Wu, Mingyi.,Xu, Li.,Lian, Wu.,Xiang, Jingying.,...&Zhao, Jinhua.(2013).Comparison of Physicochemical Characteristics and Anticoagulant Activities of Polysaccharides from Three Sea Cucumbers.MARINE DRUGS,11(2),399-417.
MLA Luo, Lan,et al."Comparison of Physicochemical Characteristics and Anticoagulant Activities of Polysaccharides from Three Sea Cucumbers".MARINE DRUGS 11.2(2013):399-417.
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