Norfriedelins A-C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata) | |
Liu, Jie-Qing1; Peng, Xing-Rong1,2; Li, Xu-Yang1,2; Li, Ting-Zhao3; Zhang, Wei-Ming1,2; Shi, Lei1; Han, Jiang3; Qiu, Ming-Hua1,2 | |
通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; mhchiu@mail.kib.ac.cn |
2013-04-05 | |
发表期刊 | ORGANIC LETTERS |
ISSN | 1523-7060 |
卷号 | 15期号:7页码:1580-1583 |
摘要 | Three novel norfriedelanes, A-C (1-3), were isolated from the branches and roots of Malpighia emarginata. Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an alpha-oxo-beta-lactone group) and norfriedelin B (with a keto-lactone group) showed acetylcholinesterase inhibitory effects with the IC50 values of 10.3 and 28.7 mu m, respectively. |
关键词 | Lines In-vitro Friedelane Triterpenoids Cholinergic Hypothesis Secofriedelane Assignments Growth Fruit H-1 |
学科领域 | Chemistry, Organic |
收录类别 | SCI ; IC |
语种 | 英语 |
WOS记录号 | WOS:000317327900041 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/16535 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Amway China Bot Res Ctr, Wuxi 214115, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Jie-Qing,Peng, Xing-Rong,Li, Xu-Yang,et al. Norfriedelins A-C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata)[J]. ORGANIC LETTERS,2013,15(7):1580-1583. |
APA | Liu, Jie-Qing.,Peng, Xing-Rong.,Li, Xu-Yang.,Li, Ting-Zhao.,Zhang, Wei-Ming.,...&Qiu, Ming-Hua.(2013).Norfriedelins A-C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata).ORGANIC LETTERS,15(7),1580-1583. |
MLA | Liu, Jie-Qing,et al."Norfriedelins A-C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata)".ORGANIC LETTERS 15.7(2013):1580-1583. |
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