Norfriedelins A-C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata)
Liu, Jie-Qing1; Peng, Xing-Rong1,2; Li, Xu-Yang1,2; Li, Ting-Zhao3; Zhang, Wei-Ming1,2; Shi, Lei1; Han, Jiang3; Qiu, Ming-Hua1,2
2013-04-05
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号15期号:7页码:1580-1583
摘要Three novel norfriedelanes, A-C (1-3), were isolated from the branches and roots of Malpighia emarginata. Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an alpha-oxo-beta-lactone group) and norfriedelin B (with a keto-lactone group) showed acetylcholinesterase inhibitory effects with the IC50 values of 10.3 and 28.7 mu m, respectively.
关键词Lines In-vitro Friedelane Triterpenoids Cholinergic Hypothesis Secofriedelane Assignments Growth Fruit H-1
资助信息Amway RD project [RD20111027Z]; NSFC [81202437]; High-Tech Special Project of Yunnan Province [0703C51211]; CAS [Y0225211Y1]; Major Drug Discovery Project of MOST [2011ZX09307-002-02]
学科领域Chemistry, Organic
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000317327900041
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16535
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Amway China Bot Res Ctr, Wuxi 214115, Peoples R China
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Liu, Jie-Qing,Peng, Xing-Rong,Li, Xu-Yang,et al. Norfriedelins A-C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata)[J]. ORGANIC LETTERS,2013,15(7):1580-1583.
APA Liu, Jie-Qing.,Peng, Xing-Rong.,Li, Xu-Yang.,Li, Ting-Zhao.,Zhang, Wei-Ming.,...&Qiu, Ming-Hua.(2013).Norfriedelins A-C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata).ORGANIC LETTERS,15(7),1580-1583.
MLA Liu, Jie-Qing,et al."Norfriedelins A-C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata)".ORGANIC LETTERS 15.7(2013):1580-1583.
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