A new family of cystine knot peptides from the seeds of Momordica cochinchinensis

	A new family of cystine knot peptides from the seeds of Momordica cochinchinensis
	Chan, Lai Yue 1; He, Wenjun 2; Tan, Ninghua 2; Zeng, Guangzhi 2; Craik, David J.1; Daly, Norelle L.1,3
通讯作者	Daly, NL (reprint author), Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia. ; nhtan@mail.kib.ac.cn ; norelle.daly@jcu.edu.au
	2013
发表期刊	PEPTIDES
ISSN	0196-9781
卷号	39 页码:29-35
摘要	Momordica cochinchinensis, a Cucurbitaceae plant commonly found in Southeast Asia, has the unusual property of containing both acyclic and backbone-cyclized trypsin inhibitors with inhibitor cystine knot (ICK) motifs. In the current study we have shown that M. cochinchinensis also contains another family of acyclic ICK peptides. We recently reported two novel peptides from M. cochinchinensis but have now discovered four additional peptides (MCo-3-MCo-6) with related sequences. Together these peptides form a novel family of M. cochinchinensis ICK( peptides (MCo-ICK) that do not have sequence homology with other known peptides and are not potent trypsin inhibitors. Otherwise these new peptides MCo-3 to MCo-6 were evaluated for antimalarial activity against Plasmodium falciparum, and cytotoxic activity against the cancer cell line MDA-MB-231. But these peptides were not active. (C) 2012 Elsevier Inc. All rights reserved.
关键词	Cystine Knot Peptides Mco-3 To Mco-6 Momordica Cochinchinensis
学科领域	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
收录类别	SCI
语种	英语
WOS记录号	WOS:000315839300006
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16531
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.James Cook Univ, Sch Pharm & Mol Sci, Ctr Biodiscoveiy & Mol Dev Therapeut, Queensland Trop Hlth Alliance, Cairns, Qld 4870, Australia
推荐引用方式 GB/T 7714	Chan, Lai Yue,He, Wenjun,Tan, Ninghua,et al. A new family of cystine knot peptides from the seeds of Momordica cochinchinensis[J]. PEPTIDES,2013,39:29-35.
APA	Chan, Lai Yue,He, Wenjun,Tan, Ninghua,Zeng, Guangzhi,Craik, David J.,&Daly, Norelle L..(2013).A new family of cystine knot peptides from the seeds of Momordica cochinchinensis.PEPTIDES,39,29-35.
MLA	Chan, Lai Yue,et al."A new family of cystine knot peptides from the seeds of Momordica cochinchinensis".PEPTIDES 39(2013):29-35.

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