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题名: A new family of cystine knot peptides from the seeds of Momordica cochinchinensis
作者: Chan, Lai Yue1; He, Wenjun2; Tan, Ninghua2; Zeng, Guangzhi2; Craik, David J.1; Daly, Norelle L.1, 3
刊名: PEPTIDES
关键词: Cystine knot ; Peptides ; MCo-3 to MCo-6 ; Momordica cochinchinensis
英文摘要: Momordica cochinchinensis, a Cucurbitaceae plant commonly found in Southeast Asia, has the unusual property of containing both acyclic and backbone-cyclized trypsin inhibitors with inhibitor cystine knot (ICK) motifs. In the current study we have shown that M. cochinchinensis also contains another family of acyclic ICK peptides. We recently reported two novel peptides from M. cochinchinensis but have now discovered four additional peptides (MCo-3-MCo-6) with related sequences. Together these peptides form a novel family of M. cochinchinensis ICK( peptides (MCo-ICK) that do not have sequence homology with other known peptides and are not potent trypsin inhibitors. Otherwise these new peptides MCo-3 to MCo-6 were evaluated for antimalarial activity against Plasmodium falciparum, and cytotoxic activity against the cancer cell line MDA-MB-231. But these peptides were not active. (C) 2012 Elsevier Inc. All rights reserved.
出版日期: 2013
卷号: 39, 页码:29-35
语种: 英语
ISSN号: 0196-9781
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16531
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.James Cook Univ, Sch Pharm & Mol Sci, Ctr Biodiscoveiy & Mol Dev Therapeut, Queensland Trop Hlth Alliance, Cairns, Qld 4870, Australia

Recommended Citation:
Chan, Lai Yue; He, Wenjun; Tan, Ninghua; Zeng, Guangzhi; Craik, David J.; Daly, Norelle L..A new family of cystine knot peptides from the seeds of Momordica cochinchinensis,PEPTIDES,2013,39():29-35
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