| Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii | |
Cao, Tuan-Wu1,3; Geng, Chang-An1 ; Ma, Yun-Bao1; He, Kang1; Wang, Hong-Ling1,3; Zhou, Ning-Jia1,3; Zhang, Xue-Mei1; Tao, Yan-Duo2; Chen, Ji-Jun1
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| 通讯作者 | Chen,JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China. |
| 2013-05-01 | |
| 发表期刊 | PLANTA MEDICA
 |
| ISSN | 0032-0943 |
| 卷号 | 79期号:8页码:697-700 |
| 摘要 | Two new xanthones, 8-O-beta-D-glucopyranosyl-1-hydroxy-2,3,5-trimethoxyxanthone (1) and 8-O-[beta-D-xylopyranosyl-(1 -> 6)-beta-D-glucopyranosyl]-1-hydroxy-2,3,5-trimethoxyxanthone (2), along with eighteen known xanthones (3-20) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [alpha](D)). All compounds were evaluated for their anti-hepatitis B virus activities on HepG 2.2.15 cells line in vitro, and compounds 3-10 exhibited significant activity inhibiting hepatitis B virus DNA replication with IC50 values from 0.01 mM to 0.13 mM. Compounds 3-5 showed remarkable activity with IC50 values of 0.77, >0.98, and 0.21 mM for HBsAg, and <0.62, 0.35, and 0.04 mM for HBeAg, respectively. Meanwhile, the effects of different substitutions on the anti-hepatitis B virus activity of xanthones from S. mussotii were discussed. |
| 关键词 | Swertia Mussotii Gentianaceae Xanthones Anti-hbv Activity |
| 学科领域 | Plant Sciences ; Medicinal ; Chemistry ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319466800015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16529 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Res Ctr Biol Resources Qinghai Tibet Plateau, Xining, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Tuan-Wu,Geng, Chang-An,Ma, Yun-Bao,et al. Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii[J]. PLANTA MEDICA,2013,79(8):697-700. |
| APA | Cao, Tuan-Wu.,Geng, Chang-An.,Ma, Yun-Bao.,He, Kang.,Wang, Hong-Ling.,...&Chen, Ji-Jun.(2013).Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii.PLANTA MEDICA,79(8),697-700. |
| MLA | Cao, Tuan-Wu,et al."Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii".PLANTA MEDICA 79.8(2013):697-700. |
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