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题名: Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii
作者: Cao, Tuan-Wu1, 3; Geng, Chang-An1; Ma, Yun-Bao1; He, Kang1; Wang, Hong-Ling1, 3; Zhou, Ning-Jia1, 3; Zhang, Xue-Mei1; Tao, Yan-Duo2; null(陈纪军)1
刊名: PLANTA MEDICA
关键词: Swertia mussotii ; Gentianaceae ; xanthones ; anti-HBV activity
英文摘要: Two new xanthones, 8-O-beta-D-glucopyranosyl-1-hydroxy-2,3,5-trimethoxyxanthone (1) and 8-O-[beta-D-xylopyranosyl-(1 -> 6)-beta-D-glucopyranosyl]-1-hydroxy-2,3,5-trimethoxyxanthone (2), along with eighteen known xanthones (3-20) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [alpha](D)). All compounds were evaluated for their anti-hepatitis B virus activities on HepG 2.2.15 cells line in vitro, and compounds 3-10 exhibited significant activity inhibiting hepatitis B virus DNA replication with IC50 values from 0.01 mM to 0.13 mM. Compounds 3-5 showed remarkable activity with IC50 values of 0.77, >0.98, and 0.21 mM for HBsAg, and <0.62, 0.35, and 0.04 mM for HBeAg, respectively. Meanwhile, the effects of different substitutions on the anti-hepatitis B virus activity of xanthones from S. mussotii were discussed.
出版日期: 2013-05-01
卷号: 79, 期号:8, 页码:697-700
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry ; Medicinal; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16529
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Res Ctr Biol Resources Qinghai Tibet Plateau, Xining, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
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