Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton
Han, Quan-Bin; Cheung, Susan; Tai, Joseph; Qiao, Chun-Feng; Song, Jing-Zheng; Tso, Ting-Fai; Sun, Han-Dong; Xu, Hong-Xi
2006-10-12
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume8Issue:21Pages:4727-4730
AbstractA novel diterpene with an unprecedented tetracyclic 6,7:8,15-di-seco-7,20-olide-6,8-cyclo-ent-kaurane skeleton, named maoecrystal Z (1), has been isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx (Labiatae). Its structure was determined by comprehensive NMR and MS spectroscopic analysis coupled with single-crystal X-ray crystallographic diffraction. Compound 1 exhibited comparable inhibitory effect against human K562 leukemia, MCF7 breast, and A2780 ovarian tumor cells with IC(50) = 2.90, 1.63, and 1.45 mu g/mL and with camptothecin and paclitaxel as the positive controls.
KeywordEnt-kaurane Diterpenoids Rubescens Var.-taihangensis Dimer Laxiflora Oridonin Crystal
Subject AreaChemistry ; Organic
DOI10.1021/ol061757j
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000241030900015
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/1649
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Hong Kong, Hong Kong, Peoples R China
2.Univ British Columbia, Ctr Complementary Med Res, Child & Family Res Inst, Dept Pathol, Vancouver, BC V5Z 1M9, Canada
3.Univ British Columbia, Ctr Complementary Med Res, Child & Family Res Inst, Dept Pediat, Vancouver, BC V5Z 1M9, Canada
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Han, Quan-Bin,Cheung, Susan,Tai, Joseph,et al. Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton[J]. ORGANIC LETTERS,2006,8(21):4727-4730.
APA Han, Quan-Bin.,Cheung, Susan.,Tai, Joseph.,Qiao, Chun-Feng.,Song, Jing-Zheng.,...&Xu, Hong-Xi.(2006).Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton.ORGANIC LETTERS,8(21),4727-4730.
MLA Han, Quan-Bin,et al."Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton".ORGANIC LETTERS 8.21(2006):4727-4730.
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