Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors Through an Oriented Screening on Natural Products
Li Wen-gui1; Dai Fei-yan1; Cheng Yong-xian2; Yin Ge-fen1; Bi Jun-long1; Li Dian-peng3
Corresponding AuthorCheng, YX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China. ; yxcheng@mail.kib.ac.cn
2013-04-01
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume29Issue:2Pages:290-293
AbstractPorcine reproductive and respiratory syndrome(PRRS) caused by porcine reproductive and respiratory syndrome virus(PRRSV) is one of the most infectious diseases in the swine industry worldwide, causing big economic losses. Vaccines are major weapons against PRRSV, however, current available vaccines have several limitations. Developing chemical drugs as alternatives is required. On the basis of traditional medical knowledge, we purposely selected 15 natural products originated from Chinese herbs with anti-infectious effects. Their antiviral activities were evaluated by PRRSV-induced cytopathic effect(CPE) on MARC-145 cells and reverse transcription polymerase chain reaction(RT-PCR) assay. Compounds ethoxysanguinarine(EOSG) and atractylodinol were found to be the hits which could significantly reduce PRRSV-associated CPE with 50% inhibited concentration(IC50) values of 7.9 and 39.4 mu mol/L, respectively. Meanwhile, compounds ethoxysanguinarine and atractylodinol significantly decreased mRNA expression of ORF7 gene in a dose-dependent manner. Study results suggest that compounds ethoxysanguinarine and atractylodinol may be useful anti-PRRSV drugs for swine industry or the hits for further lead optimization.
KeywordPorcine Reproductive And Respiratory Syndrome Virus(Prrsv) Natural Product Cytopathic Effect Antiviral Activity
Subject AreaChemistry
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000317165900021
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16469
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China
Recommended Citation
GB/T 7714
Li Wen-gui,Dai Fei-yan,Cheng Yong-xian,et al. Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors Through an Oriented Screening on Natural Products[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2013,29(2):290-293.
APA Li Wen-gui,Dai Fei-yan,Cheng Yong-xian,Yin Ge-fen,Bi Jun-long,&Li Dian-peng.(2013).Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors Through an Oriented Screening on Natural Products.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,29(2),290-293.
MLA Li Wen-gui,et al."Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors Through an Oriented Screening on Natural Products".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 29.2(2013):290-293.
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