Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors Through an Oriented Screening on Natural Products
Li Wen-gui1; Dai Fei-yan1; Cheng Yong-xian2; Yin Ge-fen1; Bi Jun-long1; Li Dian-peng3
2013-04-01
发表期刊CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
卷号29期号:2页码:290-293
摘要Porcine reproductive and respiratory syndrome(PRRS) caused by porcine reproductive and respiratory syndrome virus(PRRSV) is one of the most infectious diseases in the swine industry worldwide, causing big economic losses. Vaccines are major weapons against PRRSV, however, current available vaccines have several limitations. Developing chemical drugs as alternatives is required. On the basis of traditional medical knowledge, we purposely selected 15 natural products originated from Chinese herbs with anti-infectious effects. Their antiviral activities were evaluated by PRRSV-induced cytopathic effect(CPE) on MARC-145 cells and reverse transcription polymerase chain reaction(RT-PCR) assay. Compounds ethoxysanguinarine(EOSG) and atractylodinol were found to be the hits which could significantly reduce PRRSV-associated CPE with 50% inhibited concentration(IC50) values of 7.9 and 39.4 mu mol/L, respectively. Meanwhile, compounds ethoxysanguinarine and atractylodinol significantly decreased mRNA expression of ORF7 gene in a dose-dependent manner. Study results suggest that compounds ethoxysanguinarine and atractylodinol may be useful anti-PRRSV drugs for swine industry or the hits for further lead optimization.
关键词Porcine Reproductive And Respiratory Syndrome Virus(Prrsv) Natural Product Cytopathic Effect Antiviral Activity
资助信息Project of Talent Scholarship for the Youth of Yunnan Province of China [2007PY01-48]; Sino-German International Collaboration Project from Yunnan Province of China [2009AC011]; Project of Natural Compound Library Construction from Chinese Academy of Sciences [KSCX2-EW-R-15]; Yunnan Provincial Program for Excellent Scientists, China [2009CI125]
学科领域Chemistry
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000317165900021
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16469
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China
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Li Wen-gui,Dai Fei-yan,Cheng Yong-xian,et al. Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors Through an Oriented Screening on Natural Products[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2013,29(2):290-293.
APA Li Wen-gui,Dai Fei-yan,Cheng Yong-xian,Yin Ge-fen,Bi Jun-long,&Li Dian-peng.(2013).Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors Through an Oriented Screening on Natural Products.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,29(2),290-293.
MLA Li Wen-gui,et al."Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors Through an Oriented Screening on Natural Products".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 29.2(2013):290-293.
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