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题名: Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors Through an Oriented Screening on Natural Products
作者: Li Wen-gui1; Dai Fei-yan1; null(程永现)2; Yin Ge-fen1; Bi Jun-long1; Li Dian-peng3
刊名: CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
关键词: Porcine reproductive and respiratory syndrome virus(PRRSV) ; Natural product ; Cytopathic effect ; Antiviral activity
英文摘要: Porcine reproductive and respiratory syndrome(PRRS) caused by porcine reproductive and respiratory syndrome virus(PRRSV) is one of the most infectious diseases in the swine industry worldwide, causing big economic losses. Vaccines are major weapons against PRRSV, however, current available vaccines have several limitations. Developing chemical drugs as alternatives is required. On the basis of traditional medical knowledge, we purposely selected 15 natural products originated from Chinese herbs with anti-infectious effects. Their antiviral activities were evaluated by PRRSV-induced cytopathic effect(CPE) on MARC-145 cells and reverse transcription polymerase chain reaction(RT-PCR) assay. Compounds ethoxysanguinarine(EOSG) and atractylodinol were found to be the hits which could significantly reduce PRRSV-associated CPE with 50% inhibited concentration(IC50) values of 7.9 and 39.4 mu mol/L, respectively. Meanwhile, compounds ethoxysanguinarine and atractylodinol significantly decreased mRNA expression of ORF7 gene in a dose-dependent manner. Study results suggest that compounds ethoxysanguinarine and atractylodinol may be useful anti-PRRSV drugs for swine industry or the hits for further lead optimization.
出版日期: 2013-04-01
卷号: 29, 期号:2, 页码:290-293
语种: 英语
收录类别: SCI
学科分类: Chemistry
ISSN号: 1005-9040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16469
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China

Recommended Citation:
Li Wen-gui; Dai Fei-yan; Cheng Yong-xian; Yin Ge-fen; Bi Jun-long; Li Dian-peng.Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors Through an Oriented Screening on Natural Products,CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2013,29(2):290-293
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