Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis
Wang, Hong-Ling1,2; Cao, Tuan-Wu1,2; Jiang, Fu-Qiang1; Geng, Chang-An1; Zhang, Xue-Mei1; Huang, Xiao-Yan1; Wang, Li-Jun1; Kang-He, Sing Wd1; Hao-Chen1,2; Liang, Wen-Juan1,2; Rong, Guang-Qing1,2; Chen, Ji-Jun1
2013-05-22
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号54期号:21页码:2710-2712
摘要Swerpunilactones A (1) and B (2), two novel xanthone and secoiridoid heterodimers, together with their presumed biosynthetic precursors (+/-)-gentiolactone (3), bellidifolin (4), and norbellidifolin (5), were isolated from the whole plants of Swertia species. A plausible biogenetic pathway for swerpunilactones A and B was proposed. In vitro anti-hepatitis B virus assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited activities against the secretion of HBsAg (IC50 = 0.25 and 0.29 mM), HBeAg (IC50 = 0.86 and 0.31 mM), and HBV DNA replication (IC50 = 0.18 and 0.19 mM). (c) 2013 Elsevier Ltd. All rights reserved.
关键词Swerpunilactones A-b Anti-hbv Activity Swertia Punicea Swertia Hispidicalyx Swertia Yunnanensis
资助信息Natural National Science Foundation of China for Distinguished Young Scholars [81025023]; National Natural Science Foundation of China and Yunnan Province [U0832603]; West Light Foundation of the Chinese Academy of Sciences; International Foundation for Science [F/5202-1]
学科领域Chemistry
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000318393000037
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16455
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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Wang, Hong-Ling,Cao, Tuan-Wu,Jiang, Fu-Qiang,et al. Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis[J]. TETRAHEDRON LETTERS,2013,54(21):2710-2712.
APA Wang, Hong-Ling.,Cao, Tuan-Wu.,Jiang, Fu-Qiang.,Geng, Chang-An.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2013).Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis.TETRAHEDRON LETTERS,54(21),2710-2712.
MLA Wang, Hong-Ling,et al."Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis".TETRAHEDRON LETTERS 54.21(2013):2710-2712.
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