Anti-HBV active constituents from Piper longum

doi:10.1016/j.bmcl.2013.01.118

	Anti-HBV active constituents from Piper longum
	Jiang, Zhi-Yong; Liu, Wen-Feng; Zhang, Xue-Mei; Luo, Jie; Ma, Yun-Bao; Chen, Ji-Jun
通讯作者	Jiang, ZY (reprint author), State Ethn Affairs Commiss, Key Lab Chem Ethn Med Resources, Kunming 650500, Yunnan, Peoples R China. ; jiangzy2010@163.com ; chenjj@mail.kib.ac.cn
	2013-04-01
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN	0960-894X
卷号	23 期号:7 页码:2123-2127
摘要	In the screening search for Hepatitis B virus inhibitory agents from medicinal plants, the ethanol extract of Piper longum Linn. was found to possess superior anti-HBV activity in vitro. Bioassay-guided fractionation coupled with repeated purification resulted in the isolation of four new compounds, involving two new glycosides longumosides A (1) and B (2) and two new amide alkaloids erythro-1-[1-oxo-9(3,4-methylenedioxyphenyl)-8,9-dihydroxy-2E-nonenyl]-piperidine (3), threo-1-[1-oxo-9(3,4-methylenedioxyphenyl)-8,9-dihydroxy-2E-nonenyl]-piperidine (4), as well as two compounds 3 beta,4 alpha-dihydroxy-2-piperidinone (5), 5,6-dihydro-2(1H)-pyridinone (6) from natural source for the first time. The structures of the four new compounds were determined by extensive analyses of the MS, IR, 1D and 2D NMR data. Besides, the compounds 2-6, together with the known compounds 7-11 obtained previously, were assayed for their anti-HBV activity by using Hep G 2.2.15 cell line in vitro. Results suggested the compound piperine (7) possessed remarkable inhibitory HBV activity, against the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with the Selectivity Index (SI) values of 15.7 and 16.8, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
关键词	Piper Longum Longumoside Amide Alkaloids Anti-hbv Activity
学科领域	Pharmacology & Pharmacy ; Chemistry
DOI	10.1016/j.bmcl.2013.01.118
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000316642900042
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16435
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resource West Chi, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Zhi-Yong,Liu, Wen-Feng,Zhang, Xue-Mei,et al. Anti-HBV active constituents from Piper longum[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(7):2123-2127.
APA	Jiang, Zhi-Yong,Liu, Wen-Feng,Zhang, Xue-Mei,Luo, Jie,Ma, Yun-Bao,&Chen, Ji-Jun.(2013).Anti-HBV active constituents from Piper longum.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(7),2123-2127.
MLA	Jiang, Zhi-Yong,et al."Anti-HBV active constituents from Piper longum".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.7(2013):2123-2127.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Jiang-2013-Anti-HBV （423KB）			开放获取	--	浏览下载