Anti-HBV active constituents from Piper longum
Jiang, Zhi-Yong; Liu, Wen-Feng; Zhang, Xue-Mei; Luo, Jie; Ma, Yun-Bao; Chen, Ji-Jun
2013-04-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号23期号:7页码:2123-2127
摘要In the screening search for Hepatitis B virus inhibitory agents from medicinal plants, the ethanol extract of Piper longum Linn. was found to possess superior anti-HBV activity in vitro. Bioassay-guided fractionation coupled with repeated purification resulted in the isolation of four new compounds, involving two new glycosides longumosides A (1) and B (2) and two new amide alkaloids erythro-1-[1-oxo-9(3,4-methylenedioxyphenyl)-8,9-dihydroxy-2E-nonenyl]-piperidine (3), threo-1-[1-oxo-9(3,4-methylenedioxyphenyl)-8,9-dihydroxy-2E-nonenyl]-piperidine (4), as well as two compounds 3 beta,4 alpha-dihydroxy-2-piperidinone (5), 5,6-dihydro-2(1H)-pyridinone (6) from natural source for the first time. The structures of the four new compounds were determined by extensive analyses of the MS, IR, 1D and 2D NMR data. Besides, the compounds 2-6, together with the known compounds 7-11 obtained previously, were assayed for their anti-HBV activity by using Hep G 2.2.15 cell line in vitro. Results suggested the compound piperine (7) possessed remarkable inhibitory HBV activity, against the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with the Selectivity Index (SI) values of 15.7 and 16.8, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Piper Longum Longumoside Amide Alkaloids Anti-hbv Activity
资助信息National Natural Science Foundation of China (NSFC) [21162041]; Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission 82 Ministry of Education, Yunnan University of Nationalities [11HXYJS05]
学科领域Pharmacology & Pharmacy ; Chemistry
DOI10.1016/j.bmcl.2013.01.118
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000316642900042
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16435
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resource West Chi, Kunming 650204, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Zhi-Yong,Liu, Wen-Feng,Zhang, Xue-Mei,et al. Anti-HBV active constituents from Piper longum[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(7):2123-2127.
APA Jiang, Zhi-Yong,Liu, Wen-Feng,Zhang, Xue-Mei,Luo, Jie,Ma, Yun-Bao,&Chen, Ji-Jun.(2013).Anti-HBV active constituents from Piper longum.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(7),2123-2127.
MLA Jiang, Zhi-Yong,et al."Anti-HBV active constituents from Piper longum".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.7(2013):2123-2127.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Jiang-2013-Anti-HBV (423KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jiang, Zhi-Yong]的文章
[Liu, Wen-Feng]的文章
[Zhang, Xue-Mei]的文章
百度学术
百度学术中相似的文章
[Jiang, Zhi-Yong]的文章
[Liu, Wen-Feng]的文章
[Zhang, Xue-Mei]的文章
必应学术
必应学术中相似的文章
[Jiang, Zhi-Yong]的文章
[Liu, Wen-Feng]的文章
[Zhang, Xue-Mei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。