New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities
Gao, Xue-Mei1,2; Li, Yun-Qi1,2; Shu, Li-Dan1,2; Shen, Yan-Qiong1,2; Yang, Li-Ying1,2; Yang, Liu-Meng4,5; Zheng Yong-Tang4,5; Sun, Han-Dong3; Xiao, Wei-Lie3; Hu, Qiu-Fen1,2
2013-03-20
发表期刊BULLETIN OF THE KOREAN CHEMICAL SOCIETY
ISSN0253-2964
卷号34期号:3页码:827-830
摘要Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated. nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 mu g/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 mu M, respectively.
关键词Schisandra Wilsoniana Nortriterpenoid Anti-hiv-1 Activity Cytotoxicity
资助信息Excellent Scientific and Technological Team of Yunnan High School [2010CI08]; Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team [2011HC008]; Open Research Fund Program of Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities) [2010XY08]; Excellent Scientific and Technological Team of Yunnan High School(2010CI08); Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team(2011HC008); Open Research Fund Program of Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities)(2010XY08)
学科领域Chemistry
DOI10.5012/bkcs.2013.34.3.827
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000317168200026
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16415
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
2.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
5.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China
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GB/T 7714
Gao, Xue-Mei,Li, Yun-Qi,Shu, Li-Dan,et al. New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2013,34(3):827-830.
APA Gao, Xue-Mei.,Li, Yun-Qi.,Shu, Li-Dan.,Shen, Yan-Qiong.,Yang, Li-Ying.,...&Hu, Qiu-Fen.(2013).New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities.BULLETIN OF THE KOREAN CHEMICAL SOCIETY,34(3),827-830.
MLA Gao, Xue-Mei,et al."New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities".BULLETIN OF THE KOREAN CHEMICAL SOCIETY 34.3(2013):827-830.
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