| New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities | |
Gao, Xue-Mei1,2; Li, Yun-Qi1,2; Shu, Li-Dan1,2; Shen, Yan-Qiong1,2; Yang, Li-Ying1,2; Yang, Liu-Meng4,5; Zheng Yong-Tang4,5; Sun, Han-Dong3 ; Xiao, Wei-Lie3; Hu, Qiu-Fen1,2
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| 通讯作者 | Xiao, WL (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China. ; xwl@mail.kib.ac.cn ; huqiufena@yahoo.com |
| 2013-03-20 | |
| 发表期刊 | BULLETIN OF THE KOREAN CHEMICAL SOCIETY
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| ISSN | 0253-2964 |
| 卷号 | 34期号:3页码:827-830 |
| 摘要 | Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated. nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 mu g/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 mu M, respectively. |
| 关键词 | Schisandra Wilsoniana Nortriterpenoid Anti-hiv-1 Activity Cytotoxicity |
| 学科领域 | Chemistry |
| DOI | 10.5012/bkcs.2013.34.3.827 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317168200026 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16415 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China 2.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Xue-Mei,Li, Yun-Qi,Shu, Li-Dan,et al. New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2013,34(3):827-830. |
| APA | Gao, Xue-Mei.,Li, Yun-Qi.,Shu, Li-Dan.,Shen, Yan-Qiong.,Yang, Li-Ying.,...&Hu, Qiu-Fen.(2013).New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities.BULLETIN OF THE KOREAN CHEMICAL SOCIETY,34(3),827-830. |
| MLA | Gao, Xue-Mei,et al."New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities".BULLETIN OF THE KOREAN CHEMICAL SOCIETY 34.3(2013):827-830. |
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