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题名: New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities
作者: Gao, Xue-Mei1, 2; Li, Yun-Qi1, 2; Shu, Li-Dan1, 2; Shen, Yan-Qiong1, 2; Yang, Li-Ying1, 2; Yang, Liu-Meng4, 5; Zheng Yong-Tang4, 5; null(孙汉董)3; Xiao, Wei-Lie3; Hu, Qiu-Fen1, 2
刊名: BULLETIN OF THE KOREAN CHEMICAL SOCIETY
关键词: Schisandra wilsoniana ; Nortriterpenoid ; Anti-HIV-1 activity ; Cytotoxicity
英文摘要: Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated. nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 mu g/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 mu M, respectively.
出版日期: 2013-03-20
卷号: 34, 期号:3, 页码:827-830
DOI标识: 10.5012/bkcs.2013.34.3.827
语种: 英语
收录类别: SCI
学科分类: Chemistry
ISSN号: 0253-2964
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16415
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
2.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
5.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China

Recommended Citation:
Gao, Xue-Mei; Li, Yun-Qi; Shu, Li-Dan; Shen, Yan-Qiong; Yang, Li-Ying; Yang, Liu-Meng; Zheng Yong-Tang; Sun, Han-Dong; Xiao, Wei-Lie; Hu, Qiu-Fen.New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities,BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2013,34(3):827-830
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