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题名: Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents
作者: Geng, Chang-An1; Wang, Li-Jun1; Guo, Rui-Hua1; null(陈纪军)1
刊名: MINI-REVIEWS IN MEDICINAL CHEMISTRY
关键词: Hepatitis B virus (HBV) ; small-molecule inhibitors ; nucleoside analogs ; non-nucleosides ; natural products ; synthesized compounds ; chemical modification ; patents
英文摘要: Hepatitis B virus (HBV) infection is a serious health problem worldwide, and the current treatment methods including vaccines, immunomodulators, interferons and nucleoside analogs are far from satisfactory. For the search of new anti-HBV agents, much investigation has revealed a large number of small-molecule compounds with various skeletons and promising anti-HBV activities. Although some reviews on anti-HBV progress have been published, they are mainly concentrated on the results reported in journal articles. This review provides an overview of the structural features and anti-HBV properties of the small-molecule anti-HBV inhibitors claimed in recent patents (from 2001 to 2010). These small-molecules can be structurally classified as two main types, nucleoside analogs (cyclic and acyclic nucleosides) and non-nucleosides (natural and synthesized compounds), which are declared with the activity inhibiting the secretion of HBsAg and HBeAg and HBV DNA replication in vitro, as well as anti-DHBV DNA in vivo. Especially, the non-nucleosides with diverse skeletons and novel mechanism offer prolific candidates for anti-HBV drug discovery, which are preferred to be used as adjuvant therapy for HBV infection. This paper will provide valuable information for understanding the current anti-HBV investigation and developing new anti-HBV agents.
出版日期: 2013-04-01
卷号: 13, 期号:5, 页码:749-776
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy
ISSN号: 1389-5575
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16413
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

Recommended Citation:
Geng, Chang-An; Wang, Li-Jun; Guo, Rui-Hua; Chen, Ji-Jun.Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents,MINI-REVIEWS IN MEDICINAL CHEMISTRY,2013,13(5):749-776
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