|Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents|
|Geng, Chang-An; Wang, Li-Jun; Guo, Rui-Hua; Chen, Ji-Jun
|发表期刊||MINI-REVIEWS IN MEDICINAL CHEMISTRY
|摘要||Hepatitis B virus (HBV) infection is a serious health problem worldwide, and the current treatment methods including vaccines, immunomodulators, interferons and nucleoside analogs are far from satisfactory. For the search of new anti-HBV agents, much investigation has revealed a large number of small-molecule compounds with various skeletons and promising anti-HBV activities. Although some reviews on anti-HBV progress have been published, they are mainly concentrated on the results reported in journal articles. This review provides an overview of the structural features and anti-HBV properties of the small-molecule anti-HBV inhibitors claimed in recent patents (from 2001 to 2010). These small-molecules can be structurally classified as two main types, nucleoside analogs (cyclic and acyclic nucleosides) and non-nucleosides (natural and synthesized compounds), which are declared with the activity inhibiting the secretion of HBsAg and HBeAg and HBV DNA replication in vitro, as well as anti-DHBV DNA in vivo. Especially, the non-nucleosides with diverse skeletons and novel mechanism offer prolific candidates for anti-HBV drug discovery, which are preferred to be used as adjuvant therapy for HBV infection. This paper will provide valuable information for understanding the current anti-HBV investigation and developing new anti-HBV agents.|
|关键词||Hepatitis b Virus (Hbv)
|资助信息||National Science Foundation of China ; National Natural Science Foundation of China [U0832603, 81202436]; National Natural Science Foundation of Yunnan Province [U0832603]; West Light Foundation of the Chinese Academy of Sciences; International Foundation for Science [F/5202-1]; National Science Foundation of China(81025023); National Natural Science Foundation of China(U0832603; National Natural Science Foundation of Yunnan Province(U0832603); West Light Foundation of the Chinese Academy of Sciences; International Foundation for Science(F/5202-1); 81202436)|
|作者单位||Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China|
Geng, Chang-An,Wang, Li-Jun,Guo, Rui-Hua,et al. Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2013,13(5):749-776.
Geng, Chang-An,Wang, Li-Jun,Guo, Rui-Hua,&Chen, Ji-Jun.(2013).Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents.MINI-REVIEWS IN MEDICINAL CHEMISTRY,13(5),749-776.
Geng, Chang-An,et al."Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents".MINI-REVIEWS IN MEDICINAL CHEMISTRY 13.5(2013):749-776.