Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents

	Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents
	Geng, Chang-An; Wang, Li-Jun; Guo, Rui-Hua; Chen, Ji-Jun
通讯作者	Chen, JJ (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China. ; chenjj@mail.kib.ac.cn
	2013-04-01
发表期刊	MINI-REVIEWS IN MEDICINAL CHEMISTRY
ISSN	1389-5575
卷号	13 期号:5 页码:749-776
摘要	Hepatitis B virus (HBV) infection is a serious health problem worldwide, and the current treatment methods including vaccines, immunomodulators, interferons and nucleoside analogs are far from satisfactory. For the search of new anti-HBV agents, much investigation has revealed a large number of small-molecule compounds with various skeletons and promising anti-HBV activities. Although some reviews on anti-HBV progress have been published, they are mainly concentrated on the results reported in journal articles. This review provides an overview of the structural features and anti-HBV properties of the small-molecule anti-HBV inhibitors claimed in recent patents (from 2001 to 2010). These small-molecules can be structurally classified as two main types, nucleoside analogs (cyclic and acyclic nucleosides) and non-nucleosides (natural and synthesized compounds), which are declared with the activity inhibiting the secretion of HBsAg and HBeAg and HBV DNA replication in vitro, as well as anti-DHBV DNA in vivo. Especially, the non-nucleosides with diverse skeletons and novel mechanism offer prolific candidates for anti-HBV drug discovery, which are preferred to be used as adjuvant therapy for HBV infection. This paper will provide valuable information for understanding the current anti-HBV investigation and developing new anti-HBV agents.
关键词	Hepatitis b Virus (Hbv) Small-molecule Inhibitors Nucleoside Analogs Non-nucleosides Natural Products Synthesized Compounds Chemical Modification Patents
学科领域	Pharmacology & Pharmacy
收录类别	SCI
语种	英语
WOS记录号	WOS:000317271100012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16413
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Geng, Chang-An,Wang, Li-Jun,Guo, Rui-Hua,et al. Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2013,13(5):749-776.
APA	Geng, Chang-An,Wang, Li-Jun,Guo, Rui-Hua,&Chen, Ji-Jun.(2013).Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents.MINI-REVIEWS IN MEDICINAL CHEMISTRY,13(5),749-776.
MLA	Geng, Chang-An,et al."Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents".MINI-REVIEWS IN MEDICINAL CHEMISTRY 13.5(2013):749-776.

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