| Cytotoxic Limonoids from Melia azedarach | |
Yuan, Chun-Mao2; Zhang, Yu2 ; Tang, Gui-Hua2; Li, Yan2; He, Hong-Ping2; Li, Shi-Fei2; Hou, Li2; Li, Xing-Yao2; Di, Ying-Tong2; Li, Shun-Lin2; Hua, Hui-Ming1; Hao, Xiao-Jiang2
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| 通讯作者 | Hua,HM (reprint author), Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Sch Tradit Chinese Mat Med, BOX 49, Shenyang 110016, Liaoning, Peoples R China.，huimhua@163.com |
| 2013 | |
| 发表期刊 | PLANTA MEDICA
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| ISSN | 0032-0943 |
| 卷号 | 79期号:2页码:163-168 |
| 摘要 | Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as well as three acetylated derivatives of 9 were evaluated for their cytotoxicities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) by an MTT assay. Seven limonoids (1, 6, 7, 8, 9, 9b, and 9c) showed significant inhibitory activities against tested cell lines with IC50 values ranging from 0.003 to 0.555 mu M, and their preliminary structure-activity relationships are also discussed. |
| 关键词 | Melia Azedarach Linn Meliaceae Limonoids Chemical Constituents Cytotoxicities |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000313965100011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16240 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Chun-Mao,Zhang, Yu,Tang, Gui-Hua,et al. Cytotoxic Limonoids from Melia azedarach[J]. PLANTA MEDICA,2013,79(2):163-168. |
| APA | Yuan, Chun-Mao.,Zhang, Yu.,Tang, Gui-Hua.,Li, Yan.,He, Hong-Ping.,...&Hao, Xiao-Jiang.(2013).Cytotoxic Limonoids from Melia azedarach.PLANTA MEDICA,79(2),163-168. |
| MLA | Yuan, Chun-Mao,et al."Cytotoxic Limonoids from Melia azedarach".PLANTA MEDICA 79.2(2013):163-168. |
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