中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Cytotoxic Limonoids from Melia azedarach
作者: Yuan, Chun-Mao2; Zhang, Yu2; Tang, Gui-Hua2; null(李艳)2; He, Hong-Ping2; Li, Shi-Fei2; Hou, Li2; Li, Xing-Yao2; Di, Ying-Tong2; Li, Shun-Lin2; Hua, Hui-Ming1; null(郝小江)2
刊名: PLANTA MEDICA
关键词: Melia azedarach Linn ; Meliaceae ; limonoids ; chemical constituents ; cytotoxicities
英文摘要: Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as well as three acetylated derivatives of 9 were evaluated for their cytotoxicities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) by an MTT assay. Seven limonoids (1, 6, 7, 8, 9, 9b, and 9c) showed significant inhibitory activities against tested cell lines with IC50 values ranging from 0.003 to 0.555 mu M, and their preliminary structure-activity relationships are also discussed.
出版日期: 2013
卷号: 79, 期号:2, 页码:163-168
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16240
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Cytotoxic Limonoids from Melia azedarach.pdf(134KB)----开放获取View Download

作者单位: 1.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yuan, Chun-Mao]'s Articles
[Zhang, Yu]'s Articles
[Tang, Gui-Hua]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yuan, Chun-Mao]‘s Articles
[Zhang, Yu]‘s Articles
[Tang, Gui-Hua]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Cytotoxic Limonoids from Melia azedarach.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace