Cytotoxic Limonoids from Melia azedarach
Yuan, Chun-Mao2; Zhang, Yu2; Tang, Gui-Hua2; Li, Yan2; He, Hong-Ping2; Li, Shi-Fei2; Hou, Li2; Li, Xing-Yao2; Di, Ying-Tong2; Li, Shun-Lin2; Hua, Hui-Ming1; Hao, Xiao-Jiang2
2013
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号79期号:2页码:163-168
摘要Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as well as three acetylated derivatives of 9 were evaluated for their cytotoxicities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) by an MTT assay. Seven limonoids (1, 6, 7, 8, 9, 9b, and 9c) showed significant inhibitory activities against tested cell lines with IC50 values ranging from 0.003 to 0.555 mu M, and their preliminary structure-activity relationships are also discussed.
关键词Melia Azedarach Linn Meliaceae Limonoids Chemical Constituents Cytotoxicities
资助信息NSFC [30830114]; Ministry of Science and Technology [2009CB52230, 2009CB940900]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI047]
学科领域Plant Sciences ; Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000313965100011
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16240
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
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Yuan, Chun-Mao,Zhang, Yu,Tang, Gui-Hua,et al. Cytotoxic Limonoids from Melia azedarach[J]. PLANTA MEDICA,2013,79(2):163-168.
APA Yuan, Chun-Mao.,Zhang, Yu.,Tang, Gui-Hua.,Li, Yan.,He, Hong-Ping.,...&Hao, Xiao-Jiang.(2013).Cytotoxic Limonoids from Melia azedarach.PLANTA MEDICA,79(2),163-168.
MLA Yuan, Chun-Mao,et al."Cytotoxic Limonoids from Melia azedarach".PLANTA MEDICA 79.2(2013):163-168.
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