| Synthesis of hemslecin A derivatives: A new class of hepatitis B virus inhibitors | |
Guo, Rui-Hua1; Geng, Chang-An1 ; Huang, Xiao-Yan1; Ma, Yun-Bao1; Zhang, Quan1; Wang, Li-Jun1; Zhang, Xue-Mei1; Zhang, Rong-Ping2; Chen, Ji-Jun1
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| 通讯作者 | Zhang, RP (reprint author), Kunming Med Univ, Kunming 650500, Yunnan, Peoples R China.，zhrpkm@163.com ; chenjj@mail.kib.ac.cn |
| 2013-03-01 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| ISSN | 0960-894X |
| 卷号 | 23期号:5页码:1201-1205 |
| 摘要 | A series of hemslecin A derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities, namely, inhibiting the secretion of hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and HBV DNA replication on HepG 2.2.15 cells. Most of the derivatives showed enhanced anti-HBV activities, of which compounds A1-A7, B5, C and E exhibited significant activities inhibiting HBV DNA replication with IC50 values of 2.8-11.6 mu M, comparable to that of the positive control, tenofovir. Compounds A1-A3, A5, B5, and C displayed low cytotoxicities, which resulted in high SI values of 89.7, 55.6, 77.8, >83.4, >55.8, and >150.5, respectively. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved. |
| 关键词 | Hemslecin a Derivatives Hepatitis b Virus |
| 学科领域 | Pharmacology & Pharmacy ; Chemistry |
| DOI | 10.1016/j.bmcl.2013.01.024 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000314693400008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16222 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Kunming Med Univ, Kunming 650500, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Rui-Hua,Geng, Chang-An,Huang, Xiao-Yan,et al. Synthesis of hemslecin A derivatives: A new class of hepatitis B virus inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(5):1201-1205. |
| APA | Guo, Rui-Hua.,Geng, Chang-An.,Huang, Xiao-Yan.,Ma, Yun-Bao.,Zhang, Quan.,...&Chen, Ji-Jun.(2013).Synthesis of hemslecin A derivatives: A new class of hepatitis B virus inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(5),1201-1205. |
| MLA | Guo, Rui-Hua,et al."Synthesis of hemslecin A derivatives: A new class of hepatitis B virus inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.5(2013):1201-1205. |
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