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题名: Synthesis of hemslecin A derivatives: A new class of hepatitis B virus inhibitors
作者: Guo, Rui-Hua1; Geng, Chang-An1; Huang, Xiao-Yan1; Ma, Yun-Bao1; Zhang, Quan1; Wang, Li-Jun1; Zhang, Xue-Mei1; Zhang, Rong-Ping2; null(陈纪军)1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Hemslecin A ; Derivatives ; Hepatitis B virus
英文摘要: A series of hemslecin A derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities, namely, inhibiting the secretion of hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and HBV DNA replication on HepG 2.2.15 cells. Most of the derivatives showed enhanced anti-HBV activities, of which compounds A1-A7, B5, C and E exhibited significant activities inhibiting HBV DNA replication with IC50 values of 2.8-11.6 mu M, comparable to that of the positive control, tenofovir. Compounds A1-A3, A5, B5, and C displayed low cytotoxicities, which resulted in high SI values of 89.7, 55.6, 77.8, >83.4, >55.8, and >150.5, respectively. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
出版日期: 2013-03-01
卷号: 23, 期号:5, 页码:1201-1205
DOI标识: 10.1016/j.bmcl.2013.01.024
语种: 英语
ISSN号: 0960-894X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16222
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Kunming Med Univ, Kunming 650500, Yunnan, Peoples R China

Recommended Citation:
Guo, Rui-Hua; Geng, Chang-An; Huang, Xiao-Yan; Ma, Yun-Bao; Zhang, Quan; Wang, Li-Jun; Zhang, Xue-Mei; Zhang, Rong-Ping; Chen, Ji-Jun.Synthesis of hemslecin A derivatives: A new class of hepatitis B virus inhibitors,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(5):1201-1205
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