Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides

	Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides
	Sun, Yisheng 1; Zhao, Zhao 1; Feng, Qiangsheng 1; Xu, Qinqin 1; Lu, Longxian 1; Liu, Ji-Kai 3; Zhang, Ling 3; Wu, Bin 2; Li, Yong-Quan 1
	2013
发表期刊	HELVETICA CHIMICA ACTA
ISSN	0018-019X
卷号	96 期号:1 页码:76-84
摘要	Investigation of the cultured mycelia of Cordyceps ophioglossoides resulted in the isolation and characterization of three new unusual spiro[4.5]decane sesquiterpenes, cordycepol A (1), cordycepol B (2), and cordycepol C (3), and a new fumagillol analogue, cordycol (4). Their structures were established by spectroscopic means. The cytotoxic activities were also evaluated, compounds 3 and 4 showing their IC50 values in the range of 1233 mu g/ml against HeLa and HepG2 (Table 3). In addition, 3 and 4 were not obviously harmful towards normal liver cell lines LO2, showing IC50 values above 80 mu g/ml.
关键词	Cordyceps Ophioglossoides CordyA?-?cepols a?-?A?-?c Cordycol Cytotoxic Activity Fungi
资助信息	National High Technology Research and Development Program of China [2007AA021506]; Science Foundation of Zhejiang Province [R207609]; NSFC of China [30801430]
学科领域	Chemistry
收录类别	SCI ; IC
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000313902600007
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16208
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China 2.Zhejiang Univ, Dept Ocean Sci & Engn, Hangzhou 310058, Zhejiang, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Sun, Yisheng,Zhao, Zhao,Feng, Qiangsheng,et al. Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides[J]. HELVETICA CHIMICA ACTA,2013,96(1):76-84.
APA	Sun, Yisheng.,Zhao, Zhao.,Feng, Qiangsheng.,Xu, Qinqin.,Lu, Longxian.,...&Li, Yong-Quan.(2013).Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides.HELVETICA CHIMICA ACTA,96(1),76-84.
MLA	Sun, Yisheng,et al."Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides".HELVETICA CHIMICA ACTA 96.1(2013):76-84.

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