Investigation of the cultured mycelia of Cordyceps ophioglossoides resulted in the isolation and characterization of three new unusual spiro[4.5]decane sesquiterpenes, cordycepol A (1), cordycepol B (2), and cordycepol C (3), and a new fumagillol analogue, cordycol (4). Their structures were established by spectroscopic means. The cytotoxic activities were also evaluated, compounds 3 and 4 showing their IC50 values in the range of 1233 mu g/ml against HeLa and HepG2 (Table 3). In addition, 3 and 4 were not obviously harmful towards normal liver cell lines LO2, showing IC50 values above 80 mu g/ml.
1.Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China 2.Zhejiang Univ, Dept Ocean Sci & Engn, Hangzhou 310058, Zhejiang, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
Recommended Citation:
Sun, Yisheng; Zhao, Zhao; Feng, Qiangsheng; Xu, Qinqin; Lu, Longxian; Liu, Ji-Kai; Zhang, Ling; Wu, Bin; Li, Yong-Quan.Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides,HELVETICA CHIMICA ACTA,2013,96(1):76-84
