Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides
Sun, Yisheng1; Zhao, Zhao1; Feng, Qiangsheng1; Xu, Qinqin1; Lu, Longxian1; Liu, Ji-Kai3; Zhang, Ling3; Wu, Bin2; Li, Yong-Quan1
2013
发表期刊HELVETICA CHIMICA ACTA
ISSN0018-019X
卷号96期号:1页码:76-84
摘要Investigation of the cultured mycelia of Cordyceps ophioglossoides resulted in the isolation and characterization of three new unusual spiro[4.5]decane sesquiterpenes, cordycepol A (1), cordycepol B (2), and cordycepol C (3), and a new fumagillol analogue, cordycol (4). Their structures were established by spectroscopic means. The cytotoxic activities were also evaluated, compounds 3 and 4 showing their IC50 values in the range of 1233 mu g/ml against HeLa and HepG2 (Table 3). In addition, 3 and 4 were not obviously harmful towards normal liver cell lines LO2, showing IC50 values above 80 mu g/ml.
关键词Cordyceps Ophioglossoides CordyA?-?cepols a?-?A?-?c Cordycol Cytotoxic Activity Fungi
资助信息National High Technology Research and Development Program of China [2007AA021506]; Science Foundation of Zhejiang Province [R207609]; NSFC of China [30801430]
学科领域Chemistry
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000313902600007
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16208
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China
2.Zhejiang Univ, Dept Ocean Sci & Engn, Hangzhou 310058, Zhejiang, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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Sun, Yisheng,Zhao, Zhao,Feng, Qiangsheng,et al. Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides[J]. HELVETICA CHIMICA ACTA,2013,96(1):76-84.
APA Sun, Yisheng.,Zhao, Zhao.,Feng, Qiangsheng.,Xu, Qinqin.,Lu, Longxian.,...&Li, Yong-Quan.(2013).Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides.HELVETICA CHIMICA ACTA,96(1),76-84.
MLA Sun, Yisheng,et al."Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides".HELVETICA CHIMICA ACTA 96.1(2013):76-84.
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