New glycosides from Tetracentron sinense and their cytotoxic activity
Wang, Yi-Fen; Lai, Gou-Fang; Efferth, Thomas; Cao, Jian-Xin; Luo, Shi-De
2006
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号3期号:9页码:1023-1030
摘要One novel neolignan (tetracentronsine; 1), one new indole alkaloid (= 3-(2-hydroxyethyl)-1H-indole-5-O-beta-D-glucopyranoside; 2), and two new phenol derivatives, 3-{2-[(beta-glucopyranosyl)oxy]-4,5(methylenedioxy)phenyl}propanoic acid (3) and methyl 3-{2-[(beta-glucopyranosyl)oxy]-4,5-(methylenedioxy)phenyl}propanoate (4), together with six known compounds were isolated from the stem bark of Tetracentron sinense. Their structures were determined by spectral analysis, including 1D- and 2D-NMR, and MS analyses. These compounds were tested for their cytotoxic activity against human leukaemia cells in vitro. Among them, compound 2, (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide (5), and maslinic acid (6) showed significant inhibitory activities against human leukaemia cells CCRF-CEM and its multi drug-resistant sub-line, CEM/ADR5000, with IC50, values in a range of 7.1 to 29.7 mu m.
关键词Multidrug-resistance Cell Lines Transporter Artesunate Glucosides Triterpene Bark
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1617
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.German Canc Res Ctr, D-69120 Heidelberg, Germany
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Wang, Yi-Fen,Lai, Gou-Fang,Efferth, Thomas,et al. New glycosides from Tetracentron sinense and their cytotoxic activity[J]. CHEMISTRY & BIODIVERSITY,2006,3(9):1023-1030.
APA Wang, Yi-Fen,Lai, Gou-Fang,Efferth, Thomas,Cao, Jian-Xin,&Luo, Shi-De.(2006).New glycosides from Tetracentron sinense and their cytotoxic activity.CHEMISTRY & BIODIVERSITY,3(9),1023-1030.
MLA Wang, Yi-Fen,et al."New glycosides from Tetracentron sinense and their cytotoxic activity".CHEMISTRY & BIODIVERSITY 3.9(2006):1023-1030.
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