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题名: New glycosides from Tetracentron sinense and their cytotoxic activity
作者: Wang, Yi-Fen; Lai, Gou-Fang; Efferth, Thomas; Cao, Jian-Xin; Luo, Shi-De
刊名: CHEMISTRY & BIODIVERSITY
关键词: MULTIDRUG-RESISTANCE ; CELL LINES ; TRANSPORTER ; ARTESUNATE ; GLUCOSIDES ; TRITERPENE ; BARK
英文摘要: One novel neolignan (tetracentronsine; 1), one new indole alkaloid (= 3-(2-hydroxyethyl)-1H-indole-5-O-beta-D-glucopyranoside; 2), and two new phenol derivatives, 3-{2-[(beta-glucopyranosyl)oxy]-4,5(methylenedioxy)phenyl}propanoic acid (3) and methyl 3-{2-[(beta-glucopyranosyl)oxy]-4,5-(methylenedioxy)phenyl}propanoate (4), together with six known compounds were isolated from the stem bark of Tetracentron sinense. Their structures were determined by spectral analysis, including 1D- and 2D-NMR, and MS analyses. These compounds were tested for their cytotoxic activity against human leukaemia cells in vitro. Among them, compound 2, (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide (5), and maslinic acid (6) showed significant inhibitory activities against human leukaemia cells CCRF-CEM and its multi drug-resistant sub-line, CEM/ADR5000, with IC50, values in a range of 7.1 to 29.7 mu m.
出版日期: 2006
卷号: 3, 期号:9, 页码:1023-1030
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Chemistry; Multidisciplinary
ISSN号: 1612-1872
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1617
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.German Canc Res Ctr, D-69120 Heidelberg, Germany

Recommended Citation:
Wang, YF; Lai, GF; Efferth, T; Cao, JX; Luo, SD.New glycosides from Tetracentron sinense and their cytotoxic activity,CHEMISTRY & BIODIVERSITY,2006,3(9):1023-1030
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