Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica

	Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica
	Qin, XD ; Dong, ZJ; Liu, JK ; Yang, LM ; Wang, RR ; Zheng, YT ; Lu, Y ; Wu, YS ; Zheng, QT
	2006
发表期刊	HELVETICA CHIMICA ACTA
ISSN	0018-019X
卷号	89 期号:1 页码:127-133
摘要	A novel benzofuran lactone, named concentricolide (=rel-(6R)-6-ethylbenzo[2.1-b:3,4-c']difuran-8(6H)-one; 1), was isolated along with four known compounds (friedelin, cytochalasin L-696.474, armillaramide, and russulamide) from the fruiting bodies of the xylariaceous ascomycete Daldinia concentrica. The structure of I was established by spectroscopic methods and X-ray crystallographic analysis. Its anti-HIV-1 activity was tested. Results showed that 1 inhibited HIV-1 induced cytopathic effects. The EC50 value was 0.31 mu g/ml. The therapeutic index (TI) was 247. Concentricolide exhibited the blockage (EC50 0.83 mu g/ml) on syncytium formation between HIV-1 infected cells and normal cells.
关键词	Fruiting Bodies Fungus Derivatives
学科领域	Chemistry ; Multidisciplinary
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000234988100014
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1609
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China 3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Qin, XD,Dong, ZJ,Liu, JK,et al. Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica[J]. HELVETICA CHIMICA ACTA,2006,89(1):127-133.
APA	Qin, XD.,Dong, ZJ.,Liu, JK.,Yang, LM.,Wang, RR.,...&Zheng, QT.(2006).Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica.HELVETICA CHIMICA ACTA,89(1),127-133.
MLA	Qin, XD,et al."Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica".HELVETICA CHIMICA ACTA 89.1(2006):127-133.

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