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题名: Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica
作者: Qin, XD; null(董泽军); Liu, JK; Yang, LM; Wang, RR; Zheng, YT; Lu, Y; Wu, YS; Zheng, QT
刊名: HELVETICA CHIMICA ACTA
关键词: FRUITING BODIES ; FUNGUS ; DERIVATIVES
英文摘要: A novel benzofuran lactone, named concentricolide (=rel-(6R)-6-ethylbenzo[2.1-b:3,4-c']difuran-8(6H)-one; 1), was isolated along with four known compounds (friedelin, cytochalasin L-696.474, armillaramide, and russulamide) from the fruiting bodies of the xylariaceous ascomycete Daldinia concentrica. The structure of I was established by spectroscopic methods and X-ray crystallographic analysis. Its anti-HIV-1 activity was tested. Results showed that 1 inhibited HIV-1 induced cytopathic effects. The EC50 value was 0.31 mu g/ml. The therapeutic index (TI) was 247. Concentricolide exhibited the blockage (EC50 0.83 mu g/ml) on syncytium formation between HIV-1 infected cells and normal cells.
出版日期: 2006
卷号: 89, 期号:1, 页码:127-133
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry; Multidisciplinary
ISSN号: 0018-019X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1609
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

Recommended Citation:
Qin, XD; Dong, ZJ; Liu, JK; Yang, LM; Wang, RR; Zheng, YT; Lu, Y; Wu, YS; Zheng, QT.Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica,HELVETICA CHIMICA ACTA,2006,89(1):127-133
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