Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica
Qin, XD; Dong, ZJ; Liu, JK; Yang, LM; Wang, RR; Zheng, YT; Lu, Y; Wu, YS; Zheng, QT
2006
发表期刊HELVETICA CHIMICA ACTA
ISSN0018-019X
卷号89期号:1页码:127-133
摘要A novel benzofuran lactone, named concentricolide (=rel-(6R)-6-ethylbenzo[2.1-b:3,4-c']difuran-8(6H)-one; 1), was isolated along with four known compounds (friedelin, cytochalasin L-696.474, armillaramide, and russulamide) from the fruiting bodies of the xylariaceous ascomycete Daldinia concentrica. The structure of I was established by spectroscopic methods and X-ray crystallographic analysis. Its anti-HIV-1 activity was tested. Results showed that 1 inhibited HIV-1 induced cytopathic effects. The EC50 value was 0.31 mu g/ml. The therapeutic index (TI) was 247. Concentricolide exhibited the blockage (EC50 0.83 mu g/ml) on syncytium formation between HIV-1 infected cells and normal cells.
关键词Fruiting Bodies Fungus Derivatives
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1609
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Qin, XD,Dong, ZJ,Liu, JK,et al. Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica[J]. HELVETICA CHIMICA ACTA,2006,89(1):127-133.
APA Qin, XD.,Dong, ZJ.,Liu, JK.,Yang, LM.,Wang, RR.,...&Zheng, QT.(2006).Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica.HELVETICA CHIMICA ACTA,89(1),127-133.
MLA Qin, XD,et al."Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica".HELVETICA CHIMICA ACTA 89.1(2006):127-133.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
201111040013.pdf(420KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qin, XD]的文章
[Dong, ZJ]的文章
[Liu, JK]的文章
百度学术
百度学术中相似的文章
[Qin, XD]的文章
[Dong, ZJ]的文章
[Liu, JK]的文章
必应学术
必应学术中相似的文章
[Qin, XD]的文章
[Dong, ZJ]的文章
[Liu, JK]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。