Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus | |
Su, Yao2,3; Bi, Jun-Long1; Wang, Yue-Hu3![]() ![]() | |
Corresponding Author | Yin, GF (reprint author), Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China.,yingefen383@sohu.com ; long@mail.kib.ac.cn |
2012-10-01 | |
Source Publication | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
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ISSN | 0103-5053 |
Volume | 23Issue:10Pages:1925-1932 |
Abstract | Two new quinonoids chiritalone A and B, and a new neolignan 7'E-4,9-dihydroxy3,3',5'-trimethoxy-8,4'-oxyneolign-7'-en-9'-al, along with known (-)-8-hydroxy-alpha-dunnione, digiferruginol, 2,5-dimethoxy-1,4-benzoquinone and hederagenin, were isolated from the stems of Chirita longgangensis var. hongyao. The structures of the new compounds were elucidated by detailed analysis from NMR (nuclear magnetic resonance) and MS (mass spectrometry) data, and the absolute configuration of chiritalone A was determined by single crystal X-ray diffraction analysis using the Flack parameter. The inhibitory activity of compounds against porcine respiratory and reproductive syndrome virus (PRRSV) was measured by the cytopathic effect (CPE) method. Digiferruginol and hederagenin showed weak effect on PRRSV with an IC50 value of 80.5 +/- 16.9 mu mol L-1 (SI = 19.9) and 43.2 +/- 7.4 mu mol L-1 (SI = 13.1), respectively. |
Keyword | Gesneriaceae Quinines Porcine Reproductive And Respiratory Syndrome Virus Chirita Longgangensis Var. Hongyao |
Subject Area | Chemistry, Multidisciplinary |
Indexed By | SCI ; IC |
Language | 英语 |
WOS ID | WOS:000312199200023 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.kib.ac.cn/handle/151853/15996 |
Collection | 资源植物与生物技术所级重点实验室 |
Affiliation | 1.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China 2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China 4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China |
Recommended Citation GB/T 7714 | Su, Yao,Bi, Jun-Long,Wang, Yue-Hu,et al. Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2012,23(10):1925-1932. |
APA | Su, Yao.,Bi, Jun-Long.,Wang, Yue-Hu.,Tan, Ying.,Yang, Jun.,...&Long, Chun-Lin.(2012).Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus.JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,23(10),1925-1932. |
MLA | Su, Yao,et al."Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus".JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 23.10(2012):1925-1932. |
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