Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus
Su, Yao2,3; Bi, Jun-Long1; Wang, Yue-Hu3; Tan, Ying3; Yang, Jun2,3; Liu, Hong-Xin3; Gu, Wei3; Yin, Ge-Fen1; Long, Chun-Lin3,4
2012-10-01
发表期刊JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
ISSN0103-5053
卷号23期号:10页码:1925-1932
摘要Two new quinonoids chiritalone A and B, and a new neolignan 7'E-4,9-dihydroxy3,3',5'-trimethoxy-8,4'-oxyneolign-7'-en-9'-al, along with known (-)-8-hydroxy-alpha-dunnione, digiferruginol, 2,5-dimethoxy-1,4-benzoquinone and hederagenin, were isolated from the stems of Chirita longgangensis var. hongyao. The structures of the new compounds were elucidated by detailed analysis from NMR (nuclear magnetic resonance) and MS (mass spectrometry) data, and the absolute configuration of chiritalone A was determined by single crystal X-ray diffraction analysis using the Flack parameter. The inhibitory activity of compounds against porcine respiratory and reproductive syndrome virus (PRRSV) was measured by the cytopathic effect (CPE) method. Digiferruginol and hederagenin showed weak effect on PRRSV with an IC50 value of 80.5 +/- 16.9 mu mol L-1 (SI = 19.9) and 43.2 +/- 7.4 mu mol L-1 (SI = 13.1), respectively.
关键词Gesneriaceae Quinines Porcine Reproductive And Respiratory Syndrome Virus Chirita Longgangensis Var. Hongyao
资助信息National Natural Science Foundation of China [31070288, 20972166, 31160509, 31161140345]; Yunnan Provincial Program for Excellent Scientists [2009CI125]; Key Research Direction Project of Knowledge Innovation Program for Chinese Academy of Sciences [KSCX2-EW-J-24]; Ministry of Education of China [B08044, MUC985-9, MUC98506-01000101]
学科领域Chemistry, Multidisciplinary
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000312199200023
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15996
专题资源植物与生物技术所级重点实验室
作者单位1.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
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GB/T 7714
Su, Yao,Bi, Jun-Long,Wang, Yue-Hu,et al. Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2012,23(10):1925-1932.
APA Su, Yao.,Bi, Jun-Long.,Wang, Yue-Hu.,Tan, Ying.,Yang, Jun.,...&Long, Chun-Lin.(2012).Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus.JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,23(10),1925-1932.
MLA Su, Yao,et al."Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus".JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 23.10(2012):1925-1932.
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