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题名: Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus
作者: Su, Yao2, 3; Bi, Jun-Long1; Wang YueHu(王跃虎)3; Tan, Ying3; Yang, Jun2, 3; Liu, Hong-Xin3; Gu, Wei3; Yin, Ge-Fen1; Long, Chun-Lin3, 4
刊名: JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
关键词: Gesneriaceae ; quinines ; porcine reproductive and respiratory syndrome virus ; Chirita longgangensis var. hongyao
英文摘要: Two new quinonoids chiritalone A and B, and a new neolignan 7'E-4,9-dihydroxy3,3',5'-trimethoxy-8,4'-oxyneolign-7'-en-9'-al, along with known (-)-8-hydroxy-alpha-dunnione, digiferruginol, 2,5-dimethoxy-1,4-benzoquinone and hederagenin, were isolated from the stems of Chirita longgangensis var. hongyao. The structures of the new compounds were elucidated by detailed analysis from NMR (nuclear magnetic resonance) and MS (mass spectrometry) data, and the absolute configuration of chiritalone A was determined by single crystal X-ray diffraction analysis using the Flack parameter. The inhibitory activity of compounds against porcine respiratory and reproductive syndrome virus (PRRSV) was measured by the cytopathic effect (CPE) method. Digiferruginol and hederagenin showed weak effect on PRRSV with an IC50 value of 80.5 +/- 16.9 mu mol L-1 (SI = 19.9) and 43.2 +/- 7.4 mu mol L-1 (SI = 13.1), respectively.
出版日期: 2012-10-01
卷号: 23, 期号:10, 页码:1925-1932
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Multidisciplinary
ISSN号: 0103-5053
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15996
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China

Recommended Citation:
Su, Yao; Bi, Jun-Long; Wang, Yue-Hu; Tan, Ying; Yang, Jun; Liu, Hong-Xin; Gu, Wei; Yin, Ge-Fen; Long, Chun-Lin.Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus,JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2012,23(10):1925-1932
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