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Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus
Su, Yao2,3; Bi, Jun-Long1; Wang, Yue-Hu3; Tan, Ying3; Yang, Jun2,3; Liu, Hong-Xin3; Gu, Wei3; Yin, Ge-Fen1; Long, Chun-Lin3,4
Corresponding AuthorYin, GF (reprint author), Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China.,yingefen383@sohu.com ; long@mail.kib.ac.cn
2012-10-01
Source PublicationJOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
ISSN0103-5053
Volume23Issue:10Pages:1925-1932
Abstract

Two new quinonoids chiritalone A and B, and a new neolignan 7'E-4,9-dihydroxy3,3',5'-trimethoxy-8,4'-oxyneolign-7'-en-9'-al, along with known (-)-8-hydroxy-alpha-dunnione, digiferruginol, 2,5-dimethoxy-1,4-benzoquinone and hederagenin, were isolated from the stems of Chirita longgangensis var. hongyao. The structures of the new compounds were elucidated by detailed analysis from NMR (nuclear magnetic resonance) and MS (mass spectrometry) data, and the absolute configuration of chiritalone A was determined by single crystal X-ray diffraction analysis using the Flack parameter. The inhibitory activity of compounds against porcine respiratory and reproductive syndrome virus (PRRSV) was measured by the cytopathic effect (CPE) method. Digiferruginol and hederagenin showed weak effect on PRRSV with an IC50 value of 80.5 +/- 16.9 mu mol L-1 (SI = 19.9) and 43.2 +/- 7.4 mu mol L-1 (SI = 13.1), respectively.

KeywordGesneriaceae Quinines Porcine Reproductive And Respiratory Syndrome Virus Chirita Longgangensis Var. Hongyao
Subject AreaChemistry, Multidisciplinary
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000312199200023
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15996
Collection资源植物与生物技术所级重点实验室
Affiliation1.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Su, Yao,Bi, Jun-Long,Wang, Yue-Hu,et al. Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2012,23(10):1925-1932.
APA Su, Yao.,Bi, Jun-Long.,Wang, Yue-Hu.,Tan, Ying.,Yang, Jun.,...&Long, Chun-Lin.(2012).Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus.JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,23(10),1925-1932.
MLA Su, Yao,et al."Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus".JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 23.10(2012):1925-1932.
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