Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana
Ji, Chang-Jiu1,2; Zeng, Guang-Zhi1; Han, Jing1,2; He, Wen-Jun1; Zhang, Yu-Mei1; Tan, Ning-Hua1
2012-10-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号22期号:20页码:6377-6380
摘要Zizimauritic acids A-C (1-3), three novel nortriterpenes with a unique A-nor-E-seco spiro-lactone ceanothane-type triterpene skeleton, together with 3 known triterpenes ceanothenic acid (4), betulinic acid (5), and ceanothic acid (6), were isolated from the roots of Ziziphus mauritiana. Compounds 1-4 showed cytotoxicities with the IC50 values ranging from 5.05 to 11.94 mu g/ml, and compounds 1 and 3 showed an inhibitory effect on the growth of Staphylococcus aureus with the IC50 values 2.17 and 12.79 mu g/ml. A plausible biosynthetic pathway of compounds 1-3 was proposed. (c) 2012 Elsevier Ltd. All rights reserved.
关键词Ziziphus Mauritiana Nortriterpene Zizimauritic Acids A-c Cytotoxicity Antibacterial Activity
资助信息National Natural Science Foundation of China [U1032602, 91013002, 30725048]; National New Drug Innovation Major Project of China [2011ZX09307-002-02]; National Basic Research Program of China [2009CB522300]
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2012.08.074
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000309609500013
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15938
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Ji, Chang-Jiu,Zeng, Guang-Zhi,Han, Jing,et al. Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(20):6377-6380.
APA Ji, Chang-Jiu,Zeng, Guang-Zhi,Han, Jing,He, Wen-Jun,Zhang, Yu-Mei,&Tan, Ning-Hua.(2012).Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(20),6377-6380.
MLA Ji, Chang-Jiu,et al."Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.20(2012):6377-6380.
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