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题名: Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana
作者: Ji, Chang-Jiu1, 2; Zeng, Guang-Zhi1; Han, Jing1, 2; He, Wen-Jun1; Zhang, Yu-Mei1; Tan, Ning-Hua1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Ziziphus mauritiana ; Nortriterpene ; Zizimauritic acids A-C ; Cytotoxicity ; Antibacterial activity
英文摘要: Zizimauritic acids A-C (1-3), three novel nortriterpenes with a unique A-nor-E-seco spiro-lactone ceanothane-type triterpene skeleton, together with 3 known triterpenes ceanothenic acid (4), betulinic acid (5), and ceanothic acid (6), were isolated from the roots of Ziziphus mauritiana. Compounds 1-4 showed cytotoxicities with the IC50 values ranging from 5.05 to 11.94 mu g/ml, and compounds 1 and 3 showed an inhibitory effect on the growth of Staphylococcus aureus with the IC50 values 2.17 and 12.79 mu g/ml. A plausible biosynthetic pathway of compounds 1-3 was proposed. (c) 2012 Elsevier Ltd. All rights reserved.
出版日期: 2012-10-15
卷号: 22, 期号:20, 页码:6377-6380
DOI标识: 10.1016/j.bmcl.2012.08.074
语种: 英语
ISSN号: 0960-894X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15938
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Ji, Chang-Jiu; Zeng, Guang-Zhi; Han, Jing; He, Wen-Jun; Zhang, Yu-Mei; Tan, Ning-Hua.Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(20):6377-6380
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