Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species
Ding, Zhang-Gui2; Zhao, Jiang-Yuan2; Li, Ming-Gang2; Huang, Rong2; Li, Qing-Ming1; Cui, Xiao-Long2; Zhu, Hua-Jie1; Wen, Meng-Liang2
Corresponding AuthorZhu, HJ (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China.,hjzhu@mail.kib.ac.cn ; mlwen@ynu.edu.cn
2012-11-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume75Issue:11Pages:1994-1998
AbstractGriseusms F (1) and G (2), two 2a-hydro-8a-(2-oxopropyl)-substituted spiro-naphthoquinones with a previously undescribed C-23 polyketide skeleton, were isolated from a Yunnan tin mine tailings-derived alkalophilic actinomycete, Nocardiapsis sp. YIM DT266. Their complete structure assignments with the absolute stereochemistry were elucidated by spectroscopic data, X-ray crystal diffraction, calculation of optical rotation, and CD spectroscopic analysis. Compounds 1 and 2 exhibited strong cytotoxicity (IC50 0.37-0.82 mu M) and antibacterial activity (MIC 0.80-1.65 mu g/mL) against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
KeywordStreptomyces-griseus Biological-activity Antibiotics Pyranonaphthoquinones Dihydrofusarubin Configuration
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np3004936
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000311461300020
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15928
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Yunnan Univ, Key Lab Microbial Resources, Key Lab Med Chem Nat Resources, Minist Educ,Yunnan Inst Microbiol, Kunming 650091, Peoples R China
Recommended Citation
GB/T 7714
Ding, Zhang-Gui,Zhao, Jiang-Yuan,Li, Ming-Gang,et al. Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(11):1994-1998.
APA Ding, Zhang-Gui.,Zhao, Jiang-Yuan.,Li, Ming-Gang.,Huang, Rong.,Li, Qing-Ming.,...&Wen, Meng-Liang.(2012).Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species.JOURNAL OF NATURAL PRODUCTS,75(11),1994-1998.
MLA Ding, Zhang-Gui,et al."Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species".JOURNAL OF NATURAL PRODUCTS 75.11(2012):1994-1998.
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