| Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species | |
| Ding, Zhang-Gui2; Zhao, Jiang-Yuan2; Li, Ming-Gang2; Huang, Rong2; Li, Qing-Ming1; Cui, Xiao-Long2; Zhu, Hua-Jie1; Wen, Meng-Liang2 | |
| 通讯作者 | Zhu, HJ (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China.,hjzhu@mail.kib.ac.cn ; mlwen@ynu.edu.cn |
| 2012-11-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| 卷号 | 75期号:11页码:1994-1998 |
| 摘要 | Griseusms F (1) and G (2), two 2a-hydro-8a-(2-oxopropyl)-substituted spiro-naphthoquinones with a previously undescribed C-23 polyketide skeleton, were isolated from a Yunnan tin mine tailings-derived alkalophilic actinomycete, Nocardiapsis sp. YIM DT266. Their complete structure assignments with the absolute stereochemistry were elucidated by spectroscopic data, X-ray crystal diffraction, calculation of optical rotation, and CD spectroscopic analysis. Compounds 1 and 2 exhibited strong cytotoxicity (IC50 0.37-0.82 mu M) and antibacterial activity (MIC 0.80-1.65 mu g/mL) against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) in vitro. |
| 关键词 | Streptomyces-griseus Biological-activity Antibiotics Pyranonaphthoquinones Dihydrofusarubin Configuration |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1021/np3004936 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000311461300020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15928 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Yunnan Univ, Key Lab Microbial Resources, Key Lab Med Chem Nat Resources, Minist Educ,Yunnan Inst Microbiol, Kunming 650091, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Zhang-Gui,Zhao, Jiang-Yuan,Li, Ming-Gang,et al. Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(11):1994-1998. |
| APA | Ding, Zhang-Gui.,Zhao, Jiang-Yuan.,Li, Ming-Gang.,Huang, Rong.,Li, Qing-Ming.,...&Wen, Meng-Liang.(2012).Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species.JOURNAL OF NATURAL PRODUCTS,75(11),1994-1998. |
| MLA | Ding, Zhang-Gui,et al."Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species".JOURNAL OF NATURAL PRODUCTS 75.11(2012):1994-1998. |
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