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题名: Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species
作者: Ding, Zhang-Gui2; Zhao, Jiang-Yuan2; Li, Ming-Gang2; Huang, Rong2; Li, Qing-Ming1; Cui, Xiao-Long2; Zhu, Hua-Jie1; Wen, Meng-Liang2
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: STREPTOMYCES-GRISEUS ; BIOLOGICAL-ACTIVITY ; ANTIBIOTICS ; PYRANONAPHTHOQUINONES ; DIHYDROFUSARUBIN ; CONFIGURATION
英文摘要: Griseusms F (1) and G (2), two 2a-hydro-8a-(2-oxopropyl)-substituted spiro-naphthoquinones with a previously undescribed C-23 polyketide skeleton, were isolated from a Yunnan tin mine tailings-derived alkalophilic actinomycete, Nocardiapsis sp. YIM DT266. Their complete structure assignments with the absolute stereochemistry were elucidated by spectroscopic data, X-ray crystal diffraction, calculation of optical rotation, and CD spectroscopic analysis. Compounds 1 and 2 exhibited strong cytotoxicity (IC50 0.37-0.82 mu M) and antibacterial activity (MIC 0.80-1.65 mu g/mL) against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
出版日期: 2012-11-01
卷号: 75, 期号:11, 页码:1994-1998
DOI标识: 10.1021/np3004936
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15928
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Yunnan Univ, Key Lab Microbial Resources, Key Lab Med Chem Nat Resources, Minist Educ,Yunnan Inst Microbiol, Kunming 650091, Peoples R China

Recommended Citation:
Ding, Zhang-Gui; Zhao, Jiang-Yuan; Li, Ming-Gang; Huang, Rong; Li, Qing-Ming; Cui, Xiao-Long; Zhu, Hua-Jie; Wen, Meng-Liang.Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species,JOURNAL OF NATURAL PRODUCTS,2012,75(11):1994-1998
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