| Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia | |
Wang, Hong-Ling1,2; He, Kang1,2; Geng, Chang-An1 ; Zhang, Xue-Mei1; Ma, Yun-Bao1; Luo, Jie1; Chen, Ji-Jun1
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| 通讯作者 | Chen,JJ (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China.,chenjj@mail.kib.ac.cn |
| 2012-11-01 | |
| 发表期刊 | PLANTA MEDICA
 |
| ISSN | 0032-0943 |
| 卷号 | 78期号:17页码:1867-1872 |
| 摘要 | Five unusual lactonic enamino ketones, gentiocrucines A-E (1-5), were isolated from Swertia macrosperma and S. angustifolia. Their structures were determined based on extensive spectroscopic analyses (IR, UV, MS, 1D- and 2D-NMR). By anti-HBV assay on the HepG 2.2.15 cell line in vitro, compound 1 inhibited both the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 3.14 and 3.35 mM, and compound 5 only inhibited the secretion of HBsAg with an IC50 value of 2.07 mM. |
| 关键词 | Gentiocrucines A-e Swertia Macrosperma Swertia Angustifolia Gentianaceae Lactonic Enamino Ketones Anti-hbv Activity |
| 学科领域 | Plant Sciences ; Medicinal ; Chemistry ; Pharmacology & Pharmacy |
| DOI | 10.1055/s-0032-1315392 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000311718900011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15918 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hong-Ling,He, Kang,Geng, Chang-An,et al. Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia[J]. PLANTA MEDICA,2012,78(17):1867-1872. |
| APA | Wang, Hong-Ling.,He, Kang.,Geng, Chang-An.,Zhang, Xue-Mei.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2012).Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia.PLANTA MEDICA,78(17),1867-1872. |
| MLA | Wang, Hong-Ling,et al."Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia".PLANTA MEDICA 78.17(2012):1867-1872. |
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