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题名: Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia
作者: Wang, Hong-Ling1, 2; He, Kang1, 2; Geng, Chang-An1; Zhang, Xue-Mei1; Ma, Yun-Bao1; Luo, Jie1; null(陈纪军)1
刊名: PLANTA MEDICA
关键词: gentiocrucines A-E ; Swertia macrosperma ; Swertia angustifolia ; Gentianaceae ; lactonic enamino ketones ; anti-HBV activity
英文摘要: Five unusual lactonic enamino ketones, gentiocrucines A-E (1-5), were isolated from Swertia macrosperma and S. angustifolia. Their structures were determined based on extensive spectroscopic analyses (IR, UV, MS, 1D- and 2D-NMR). By anti-HBV assay on the HepG 2.2.15 cell line in vitro, compound 1 inhibited both the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 3.14 and 3.35 mM, and compound 5 only inhibited the secretion of HBsAg with an IC50 value of 2.07 mM.
出版日期: 2012-11-01
卷号: 78, 期号:17, 页码:1867-1872
DOI标识: 10.1055/s-0032-1315392
语种: 英语
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15918
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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