Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia
Wang, Hong-Ling1,2; He, Kang1,2; Geng, Chang-An1; Zhang, Xue-Mei1; Ma, Yun-Bao1; Luo, Jie1; Chen, Ji-Jun1
2012-11-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号78期号:17页码:1867-1872
摘要Five unusual lactonic enamino ketones, gentiocrucines A-E (1-5), were isolated from Swertia macrosperma and S. angustifolia. Their structures were determined based on extensive spectroscopic analyses (IR, UV, MS, 1D- and 2D-NMR). By anti-HBV assay on the HepG 2.2.15 cell line in vitro, compound 1 inhibited both the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 3.14 and 3.35 mM, and compound 5 only inhibited the secretion of HBsAg with an IC50 value of 2.07 mM.
关键词Gentiocrucines A-e Swertia Macrosperma Swertia Angustifolia Gentianaceae Lactonic Enamino Ketones Anti-hbv Activity
资助信息Natural National Science Foundation of China for Distinguished Young Scholars [81025023]; National Natural Science Foundation of Yunnan Province [U0832603]; National Natural Science Foundation of China [U0832603]; West Light Foundation of the Chinese Academy of Sciences; Freedom Project State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ08]
学科领域Plant Sciences ; Medicinal ; Chemistry ; Pharmacology & Pharmacy
DOI10.1055/s-0032-1315392
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000311718900011
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15918
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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Wang, Hong-Ling,He, Kang,Geng, Chang-An,et al. Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia[J]. PLANTA MEDICA,2012,78(17):1867-1872.
APA Wang, Hong-Ling.,He, Kang.,Geng, Chang-An.,Zhang, Xue-Mei.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2012).Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia.PLANTA MEDICA,78(17),1867-1872.
MLA Wang, Hong-Ling,et al."Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia".PLANTA MEDICA 78.17(2012):1867-1872.
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