Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia
Wang, Hong-Ling1,2; He, Kang1,2; Geng, Chang-An1; Zhang, Xue-Mei1; Ma, Yun-Bao1; Luo, Jie1; Chen, Ji-Jun1
Corresponding AuthorChen,JJ (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China.,chenjj@mail.kib.ac.cn
2012-11-01
Source PublicationPLANTA MEDICA
ISSN0032-0943
Volume78Issue:17Pages:1867-1872
Abstract

Five unusual lactonic enamino ketones, gentiocrucines A-E (1-5), were isolated from Swertia macrosperma and S. angustifolia. Their structures were determined based on extensive spectroscopic analyses (IR, UV, MS, 1D- and 2D-NMR). By anti-HBV assay on the HepG 2.2.15 cell line in vitro, compound 1 inhibited both the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 3.14 and 3.35 mM, and compound 5 only inhibited the secretion of HBsAg with an IC50 value of 2.07 mM.

KeywordGentiocrucines A-e Swertia Macrosperma Swertia Angustifolia Gentianaceae Lactonic Enamino Ketones Anti-hbv Activity
Subject AreaPlant Sciences ; Medicinal ; Chemistry ; Pharmacology & Pharmacy
DOI10.1055/s-0032-1315392
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000311718900011
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15918
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Hong-Ling,He, Kang,Geng, Chang-An,et al. Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia[J]. PLANTA MEDICA,2012,78(17):1867-1872.
APA Wang, Hong-Ling.,He, Kang.,Geng, Chang-An.,Zhang, Xue-Mei.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2012).Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia.PLANTA MEDICA,78(17),1867-1872.
MLA Wang, Hong-Ling,et al."Gentiocrucines A-E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia".PLANTA MEDICA 78.17(2012):1867-1872.
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