Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities
Liu Xu1,2; Xue Yong-Bo2; Dong Ke2; Li Xiao-Nian2; Li Yan2; Pu Jian-Xin2; Wu Ji-Zhou1; Sun Han-Dong2
2012-11-01
发表期刊CHINESE JOURNAL OF NATURAL MEDICINES
ISSN1672-3651
卷号10期号:6页码:464-470
摘要AIM: To study the chemical constitutions of the aerial parts of Isodon rubescens in Jianshi county, Hubei Province, China. METHOD: Compounds 1-9 were isolated and purified by normal silica gel and C-18 reversed phase silica gel column chromatography, and HPLC. Their structures were elucidated by extensive spectroscopic methods (IR, UV, MS and NMR), and the absolute configuration of 1 was determined by single crystal X-ray diffraction. Compounds 1-9 were evaluated for their in vitro cytotoxicity against human tumor FIL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. RESULT: Eight ent-kaurane diterpenoids and one ent-gibberellanoid were isolated and identified. CONCLUSIONS: Compounds 1-3 (jianshirubesins G-I) were new diterpenoids, of which 2 was a rare 3, 20-epoxy-ent-kaurane with a hemiketal at C-3. Among all of the diterpenoids tested, compounds 4 and 5 exhibited moderate inhibitory activity on the proliferation of certain cancer cells.
关键词Isodon Rubescens Ent-kaurane Diterpenoids Cytotoxicity Jianshirubesins G-i
资助信息NSFC-Joint Foundation of Yunnan Province [U0832602]; National Natural Science Foundation of China [81172939]; Major State Basic Research Development Program of China [2009CB522300]; Reservation-Talent Project of Yunnan Province [2011CI043]; Major Direction Projection Foundation of CAS Intellectual Innovation Project [2010KIBA05]
学科领域Integrative & Complementary Medicine ; Pharmacology & Pharmacy
DOI10.3724/SP.J.1009.2012.00464
收录类别SCI
语种英语
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS类目Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS记录号WOS:000311882500010
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15914
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Tongji Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
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Liu Xu,Xue Yong-Bo,Dong Ke,et al. Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(6):464-470.
APA Liu Xu.,Xue Yong-Bo.,Dong Ke.,Li Xiao-Nian.,Li Yan.,...&Sun Han-Dong.(2012).Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities.CHINESE JOURNAL OF NATURAL MEDICINES,10(6),464-470.
MLA Liu Xu,et al."Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities".CHINESE JOURNAL OF NATURAL MEDICINES 10.6(2012):464-470.
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