Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities
Liu Xu1,2; Xue Yong-Bo2; Dong Ke2; Li Xiao-Nian2; Li Yan2; Pu Jian-Xin2; Wu Ji-Zhou1; Sun Han-Dong2
Corresponding AuthorWu, JZ (reprint author), Huazhong Univ Sci & Technol, Tongji Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.,ywjz@mails.tjmu.edu.cn ; hdsun@mail.kib.ac.cn
2012-11-01
Source PublicationCHINESE JOURNAL OF NATURAL MEDICINES
ISSN1672-3651
Volume10Issue:6Pages:464-470
AbstractAIM: To study the chemical constitutions of the aerial parts of Isodon rubescens in Jianshi county, Hubei Province, China. METHOD: Compounds 1-9 were isolated and purified by normal silica gel and C-18 reversed phase silica gel column chromatography, and HPLC. Their structures were elucidated by extensive spectroscopic methods (IR, UV, MS and NMR), and the absolute configuration of 1 was determined by single crystal X-ray diffraction. Compounds 1-9 were evaluated for their in vitro cytotoxicity against human tumor FIL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. RESULT: Eight ent-kaurane diterpenoids and one ent-gibberellanoid were isolated and identified. CONCLUSIONS: Compounds 1-3 (jianshirubesins G-I) were new diterpenoids, of which 2 was a rare 3, 20-epoxy-ent-kaurane with a hemiketal at C-3. Among all of the diterpenoids tested, compounds 4 and 5 exhibited moderate inhibitory activity on the proliferation of certain cancer cells.
KeywordIsodon Rubescens Ent-kaurane Diterpenoids Cytotoxicity Jianshirubesins G-i
Subject AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
DOI10.3724/SP.J.1009.2012.00464
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000311882500010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15914
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Huazhong Univ Sci & Technol, Tongji Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Liu Xu,Xue Yong-Bo,Dong Ke,et al. Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(6):464-470.
APA Liu Xu.,Xue Yong-Bo.,Dong Ke.,Li Xiao-Nian.,Li Yan.,...&Sun Han-Dong.(2012).Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities.CHINESE JOURNAL OF NATURAL MEDICINES,10(6),464-470.
MLA Liu Xu,et al."Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities".CHINESE JOURNAL OF NATURAL MEDICINES 10.6(2012):464-470.
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